BACKGROUND: To perform complete resection of locally advanced and recurrent rectal carcinoma, total pelvic exenteration (TPE) may be attempted. We identified disease-related outcomes and prognostic factors. METHODS: We conducted a single-centre review of patients who underwent TPE for rectal carcinoma over a 10-year period. RESULTS: We included 28 patients in our study. After a median follow-up of 35 months, 53.6% of patients were alive with no evidence of disease. The 3-year actuarial disease-free and overall survival rates were 52.2% and 75.1%, respectively. On univariate analysis, recurrent disease, preoperative body mass index greater than 30 and lymphatic invasion were poor prognostic factors for disease-free survival, and only lymphatic invasion predicted overall survival. Additionally, multivariate analysis identified lymphatic invasion as an independent poor prognostic factor for disease-free survival in this patient population with locally advanced and recurrent rectal carcinoma. CONCLUSION: Despite the significant morbidity, TPE can provide long-term survival in patients with rectal carcinoma. Additionally, lymphatic invasion on final pathology was an independent prognostic factor for disease-free survival.
BACKGROUND: To perform complete resection of locally advanced and recurrent rectal carcinoma, total pelvic exenteration (TPE) may be attempted. We identified disease-related outcomes and prognostic factors. METHODS: We conducted a single-centre review of patients who underwent TPE for rectal carcinoma over a 10-year period. RESULTS: We included 28 patients in our study. After a median follow-up of 35 months, 53.6% of patients were alive with no evidence of disease. The 3-year actuarial disease-free and overall survival rates were 52.2% and 75.1%, respectively. On univariate analysis, recurrent disease, preoperative body mass index greater than 30 and lymphatic invasion were poor prognostic factors for disease-free survival, and only lymphatic invasion predicted overall survival. Additionally, multivariate analysis identified lymphatic invasion as an independent poor prognostic factor for disease-free survival in this patient population with locally advanced and recurrent rectal carcinoma. CONCLUSION: Despite the significant morbidity, TPE can provide long-term survival in patients with rectal carcinoma. Additionally, lymphatic invasion on final pathology was an independent prognostic factor for disease-free survival.
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Authors: Verena Plodeck; Nuh N Rahbari; Juergen Weitz; Christoph G Radosa; Michael Laniado; Ralf-Thorsten Hoffmann; Klaus Zöphel; Bettina Beuthien-Baumann; Joerg Kotzerke; Joerg van den Hoff; Ivan Platzek Journal: Eur Radiol Date: 2018-07-06 Impact factor: 5.315
Authors: Verena Plodeck; Ivan Platzek; Johannes Streitzig; Heiner Nebelung; Sophia Blum; Jens-Peter Kühn; Ralf-Thorsten Hoffmann; Michael Laniado; Enrico Michler; Sebastian Hoberück; Klaus Zöphel; Jörg Kotzerke; Johannes Fritzmann; Jürgen Weitz; Christoph G Radosa Journal: Abdom Radiol (NY) Date: 2021-08-17