Literature DB >> 2193852

Mitochondrial mutations may increase oxidative stress: implications for carcinogenesis and aging?

B Bandy1, A J Davison.   

Abstract

The sensitivity of mitochondrial DNA to damage by mutagens predisposes mitochondria to injury on exposure of cells to genotoxins or oxidative stress. Damage to the mitochondrial genome causing mutations or loss of mitochondrial gene products, or to some nuclear genes encoding mitochondrial membrane proteins, may accelerate release of reactive species of oxygen. Such aberrant mitochondria may contribute to cellular aging and promotion of cancer.

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Year:  1990        PMID： 2193852     DOI： 10.1016/0891-5849(90)90152-9

Source DB:  PubMed          Journal:  Free Radic Biol Med        ISSN： 0891-5849            Impact factor:   7.376


  100 in total

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Review 8.  The role of mitochondrial DNA mutations in aging and sarcopenia: implications for the mitochondrial vicious cycle theory of aging.

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