Literature DB >> 21937771

FLUKA simulations of the response of tissue-equivalent proportional counters to ion beams for applications in hadron therapy and space.

T T Böhlen1, M Dosanjh, A Ferrari, I Gudowska, A Mairani.   

Abstract

For both cancer therapy with protons and ions (hadron therapy) and space radiation environments, the spatial energy deposition patterns of the radiation fields are of importance for quantifying the resulting radiation damage in biological structures. Tissue-equivalent proportional counters (TEPC) are the principal instruments for measuring imparted energy on a microscopic scale and for characterizing energy deposition patterns of radiation. Moreover, the distribution of imparted energy can serve as a complementary quantity to particle fluences of the primary beam and secondary fragments for characterizing a radiation field on a physical basis for radiobiological models. In this work, the Monte Carlo particle transport code FLUKA is used for simulating energy depositions in TEPC by ion beams. The capability of FLUKA in predicting imparted energy and derived quantities, such as lineal energy, for microscopic volumes is evaluated by comparing it with a large set of TEPC measurements for different ion beams with atomic numbers ranging from 1 to 26 and energies from 80 up to 1000 MeV/n. The influence of different physics configurations in the simulation is also discussed. It is demonstrated that FLUKA can simulate energy deposition patterns of ions in TEPC cavities accurately and that it provides an adequate description of the main features of the spectra.

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Year:  2011        PMID: 21937771     DOI: 10.1088/0031-9155/56/20/002

Source DB:  PubMed          Journal:  Phys Med Biol        ISSN: 0031-9155            Impact factor:   3.609


  5 in total

1.  The microdosimetric extension in TOPAS: development and comparison with published data.

Authors:  Hongyu Zhu; Yizheng Chen; Wonmo Sung; Aimee L McNamara; Linh T Tran; Lucas N Burigo; Anatoly B Rosenfeld; Junli Li; Bruce Faddegon; Jan Schuemann; Harald Paganetti
Journal:  Phys Med Biol       Date:  2019-07-11       Impact factor: 3.609

2.  Nontargeted stressful effects in normal human fibroblast cultures exposed to low fluences of high charge, high energy (HZE) particles: kinetics of biologic responses and significance of secondary radiations.

Authors:  Géraldine Gonon; Jean-Emmanuel Groetz; Sonia M de Toledo; Roger W Howell; Michel Fromm; Edouard I Azzam
Journal:  Radiat Res       Date:  2013-03-06       Impact factor: 2.841

3.  A new in vitro model applied 90Y microspheres to study the effects of low dose beta radiation on colorectal cancer cell line in various oxygenation conditions.

Authors:  Piotr Piasecki; Aleksandra Majewska; Jerzy Narloch; Maciej Maciak; Klaudia Brodaczewska; Michal Kuc; Halina Was; Marek Wierzbicki; Krzysztof Brzozowski; Piotr Ziecina; Andrzej Mazurek; Miroslaw Dziuk; Edward Iller; Claudine Kieda
Journal:  Sci Rep       Date:  2021-02-24       Impact factor: 4.379

4.  Estimate of the Biological Dose in Hadrontherapy Using GATE.

Authors:  Yasmine Ali; Caterina Monini; Etienne Russeil; Jean Michel Létang; Etienne Testa; Lydia Maigne; Michael Beuve
Journal:  Cancers (Basel)       Date:  2022-03-25       Impact factor: 6.639

5.  Monte Carlo Calculations Supporting Patient Plan Verification in Proton Therapy.

Authors:  Thiago V M Lima; Manjit Dosanjh; Alfredo Ferrari; Silvia Molineli; Mario Ciocca; Andrea Mairani
Journal:  Front Oncol       Date:  2016-03-18       Impact factor: 6.244

  5 in total

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