| Literature DB >> 21936769 |
Junji Yamashita1, Chiaki Iwamura, Kunitoshi Mitsumori, Hiroyuki Hosokawa, Tetsuya Sasaki, Munehisa Takahashi, Hitoshi Tanaka, Kenji Kaneko, Asami Hanazawa, Yukiko Watanabe, Kenta Shinoda, Damon Tumes, Shinichiro Motohashi, Toshinori Nakayama.
Abstract
Schnurri (Shn)-2 is a large zinc finger-containing protein implicated in cell growth, signal transduction and lymphocyte development. Here, we report that Shn-2-deficient (Shn-2(-/-)) mice develop CD3-positive lymphoma spontaneously. In Shn-2(-/-) mice, we observed decreased cytotoxicity of natural killer (NK) cells accompanied by decreased expression of perforin and granzyme-B. In addition, phosphorylation of signal transducer and activator of transcription (STAT) 5 was reduced in Shn-2(-/-) NK cells, while phosphorylation of STAT3 and protein expression of nuclear factor-κB p65 subunit were enhanced in Shn-2(-/-) NK cells. Moreover, cell-surface expression of activation molecules such as CD27, CD69 and CD122 were decreased on Shn-2(-/-) NK cells. Thus, Shn-2 is considered to play an important role in the activation and function of NK cells and the development of T cell lymphoma in vivo.Entities:
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Year: 2011 PMID： 21936769 DOI： 10.3109/10428194.2011.625099
Source DB: PubMed Journal: Leuk Lymphoma ISSN： 1026-8022