OBJECTIVES: A genetic variant (rs3800779; M30) in the KCNH2 gene has been associated with schizophrenia, a lower intelligence quotient (IQ) and processing speed scores, altered brain functions and increased KCNH2-3.1. mRNA levels in the hippocampus. The aims of this study were to investigate whether the KCNH2 polymorphism is associated with schizophrenia-related neurocognitive deficits and to confirm the association between the variant and schizophrenia. METHODS: The effects of the risk genotype on IQ and seven neurocognitive batteries were examined by the analysis of covariance in 191 healthy subjects. We performed a meta-analysis of the association between M30 and schizophrenia using five independent ethnic groups (1,720 cases; 2,418 controls). RESULTS: Consistent with the previous study, we provided evidence that subjects with the risk T carriers had significantly lower IQ scores than those with the G/G genotype (P = 0.048). Of the seven neurocognitive batteries, subjects with the risk genotype demonstrated lower performances on attention/vigilance (P = 0.0079) and working memory (P = 0.0066) relative to subjects with the G/G genotype. Meta-analysis demonstrated evidence for an association between M30 and schizophrenia without showing heterogeneity across studies (odds ratio = 1.18; P = 0.0017). CONCLUSIONS: These data suggest that the KCNH2 polymorphism could be associated with schizophrenia-related neuropsychological deficits and the risk of developing schizophrenia.
OBJECTIVES: A genetic variant (rs3800779; M30) in the KCNH2 gene has been associated with schizophrenia, a lower intelligence quotient (IQ) and processing speed scores, altered brain functions and increased KCNH2-3.1. mRNA levels in the hippocampus. The aims of this study were to investigate whether the KCNH2 polymorphism is associated with schizophrenia-related neurocognitive deficits and to confirm the association between the variant and schizophrenia. METHODS: The effects of the risk genotype on IQ and seven neurocognitive batteries were examined by the analysis of covariance in 191 healthy subjects. We performed a meta-analysis of the association between M30 and schizophrenia using five independent ethnic groups (1,720 cases; 2,418 controls). RESULTS: Consistent with the previous study, we provided evidence that subjects with the risk T carriers had significantly lower IQ scores than those with the G/G genotype (P = 0.048). Of the seven neurocognitive batteries, subjects with the risk genotype demonstrated lower performances on attention/vigilance (P = 0.0079) and working memory (P = 0.0066) relative to subjects with the G/G genotype. Meta-analysis demonstrated evidence for an association between M30 and schizophrenia without showing heterogeneity across studies (odds ratio = 1.18; P = 0.0017). CONCLUSIONS: These data suggest that the KCNH2 polymorphism could be associated with schizophrenia-related neuropsychological deficits and the risk of developing schizophrenia.
Authors: R Hashimoto; M Ikeda; F Yamashita; K Ohi; H Yamamori; Y Yasuda; M Fujimoto; M Fukunaga; K Nemoto; T Takahashi; M Tochigi; T Onitsuka; H Yamasue; K Matsuo; T Iidaka; N Iwata; M Suzuki; M Takeda; K Kasai; N Ozaki Journal: Transl Psychiatry Date: 2014-10-21 Impact factor: 6.222
Authors: Gregory V Carr; Jingshan Chen; Feng Yang; Ming Ren; Peixiong Yuan; Qingjun Tian; Audrey Bebensee; Grace Y Zhang; Jing Du; Paul Glineburg; Randy Xun; Omoye Akhile; Daniel Akuma; James Pickel; James C Barrow; Francesco Papaleo; Daniel R Weinberger Journal: Mol Psychiatry Date: 2016-02-09 Impact factor: 15.992
Authors: Nicholas E Calcaterra; Daniel J Hoeppner; Huijun Wei; Andrew E Jaffe; Brady J Maher; James C Barrow Journal: Sci Rep Date: 2016-02-16 Impact factor: 4.379
Authors: Susanne Henningsson; Anna Zettergren; Daniel Hovey; Lina Jonsson; Joakim Svärd; Diana S Cortes; Jonas Melke; Natalie C Ebner; Petri Laukka; Håkan Fischer; Lars Westberg Journal: Front Neurosci Date: 2015-10-21 Impact factor: 4.677