BACKGROUND: Although pulmonary rehabilitation is an integrated part of standard care in patients with severe COPD, it is uncertain whether those with less severe COPD benefit from such treatment. The aim of the present survey was to evaluate the effect of rehabilitation in patients with moderate COPD and to determine their willingness to participate in rehabilitation. MATERIAL AND METHODS: In a single-centre, randomized, placebo-controlled, unblinded clinical trial, participants comprised 61 of 133 referred subjects with moderate COPD. Of the 61 participants, 35 were randomized to receive rehabilitation and 26 subjects to receivestandard COPD care from their GP. After randomization 19 subjects dropped out. RESULTS: Effects of physical training were seen during the period of intervention. Compared with those receiving standard GP care, those receiving rehabilitation showed improvements in walking distance and leg strength as well as improvements in quality of life; however, the effect was temporary, and at 18 months' follow-up there was no significant difference between the groups. Only 61 subjects of the referred group of 133 with moderate COPD accepted the offer of rehabilitation. CONCLUSION: Although an effect was found of pulmonary rehabilitation in subjects with moderate COPD, it disappeared over 18 months. Only a minority of patients with moderate COPD referred for rehabilitation accepted and completed the treatment offer.
RCT Entities:
BACKGROUND: Although pulmonary rehabilitation is an integrated part of standard care in patients with severe COPD, it is uncertain whether those with less severe COPD benefit from such treatment. The aim of the present survey was to evaluate the effect of rehabilitation in patients with moderate COPD and to determine their willingness to participate in rehabilitation. MATERIAL AND METHODS: In a single-centre, randomized, placebo-controlled, unblinded clinical trial, participants comprised 61 of 133 referred subjects with moderate COPD. Of the 61 participants, 35 were randomized to receive rehabilitation and 26 subjects to receive standard COPD care from their GP. After randomization 19 subjects dropped out. RESULTS: Effects of physical training were seen during the period of intervention. Compared with those receiving standard GP care, those receiving rehabilitation showed improvements in walking distance and leg strength as well as improvements in quality of life; however, the effect was temporary, and at 18 months' follow-up there was no significant difference between the groups. Only 61 subjects of the referred group of 133 with moderate COPD accepted the offer of rehabilitation. CONCLUSION: Although an effect was found of pulmonary rehabilitation in subjects with moderate COPD, it disappeared over 18 months. Only a minority of patients with moderate COPD referred for rehabilitation accepted and completed the treatment offer.
Authors: Ofra Kalter-Leibovici; Michal Benderly; Laurence S Freedman; Galit Kaufman; Tchiya Molcho Falkenberg Luft; Havi Murad; Liraz Olmer; Meri Gluch; David Segev; Avi Gilad; Said Elkrinawi; Tali Cukierman-Yaffe; Baruch Chen; Orit Jacobson; Calanit Key; Mordechai Shani; Gershon Fink Journal: Am J Respir Crit Care Med Date: 2018-06-15 Impact factor: 21.405
Authors: Charlotte C Poot; Eline Meijer; Annemarije L Kruis; Nynke Smidt; Niels H Chavannes; Persijn J Honkoop Journal: Cochrane Database Syst Rev Date: 2021-09-08
Authors: Eline Meijer; Annelies E van Eeden; Annemarije L Kruis; Melinde R S Boland; Willem J J Assendelft; Apostolos Tsiachristas; Maureen P M H Rutten-van Mölken; Marise J Kasteleyn; Niels H Chavannes Journal: BMC Pulm Med Date: 2020-06-18 Impact factor: 3.317
Authors: Pierachille Santus; Linda Bassi; Dejan Radovanovic; Andrea Airoldi; Rita Raccanelli; Francesco Triscari; Francesca Giovannelli; Antonio Spanevello Journal: Pulm Med Date: 2013-01-09
Authors: Annemarije L Kruis; Melinde R S Boland; Catharina H Schoonvelde; Willem J J Assendelft; Maureen P M H Rutten-van Mölken; Jacobijn Gussekloo; Apostolos Tsiachristas; Niels H Chavannes Journal: BMC Pulm Med Date: 2013-03-23 Impact factor: 3.317
Authors: Annemarije L Kruis; Melinde R S Boland; Willem J J Assendelft; Jacobijn Gussekloo; Apostolos Tsiachristas; Theo Stijnen; Coert Blom; Jacob K Sont; Maureen P H M Rutten-van Mölken; Niels H Chavannes Journal: BMJ Date: 2014-09-10
Authors: Melinde R S Boland; Annemarije L Kruis; Simone A Huygens; Apostolos Tsiachristas; Willem J J Assendelft; Jacobijn Gussekloo; Coert M G Blom; Niels H Chavannes; Maureen P M H Rutten-van Mölken Journal: NPJ Prim Care Respir Med Date: 2015-12-17 Impact factor: 2.871