| Literature DB >> 21933694 |
Meixiang Sang1, Yishui Lian, Xinliang Zhou, Baoen Shan.
Abstract
The melonoma-associated antigens family A (MAGE-A) belongs to cancer/testis antigens (CTA) that are expressed in a wide variety of malignant tumors but not in normal adult tissues except for testis. Interestingly, germ cells do not express MHC class I antigen, implying that these gene products should be ideal targets for cancer immunotherapy. The strict tumor-specific expression of MAGE-As has led to several immunotherapeutic trials targeting some of these proteins. In this review, we briefly described the expression and activation mechanism of MAGE-As in cancer. We also summarized the biological functions of MAGE-As in cell progress and the progress of the cancer immunotherapy targeting MAGE-A family.Entities:
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Year: 2011 PMID： 21933694 DOI： 10.1016/j.vaccine.2011.09.014
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641