Following the publication of our article [1] an error in the discussion section was noted. In the description of the five phases of abdominal pain attacks associated with classic hereditary angioedema [2], we incorrectly stated the phases and described phase V instead of phase zero.Phase I starts with a period of non-cramping abdominal discomfort followed by (phase II) a crescendo phase which leads to (phase III) severe pain. Phase III is associated with vomiting and occasional diarrhea. Hypovolemia and hemoconcentration can occur as a result of a combination of events including vasodilatation, fluid shifts with edema of the bowel, ascites, and volume depletion related to vomiting and diarrhea. Phase IV refers to a decrescendo phase, which is a self limiting phase for untreated abdominal pain. Phase V refers to the resolution of pain, which can occur as often as twice a week
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Phase zero also known as Prephase which includes fatigue, irritability, sensitivity to noise, nausea, and erythema marginatum. Phase I starts with a period of non-cramping abdominal discomfort followed by (phase II) a crescendo phase which leads to (phase III) severe pain. Phase III is associated with vomiting and occasional diarrhea. Hypovolemia and hemoconcentration can occur as a result of a combination of events including vasodilatation, fluid shifts with edema of the bowel, ascites, and volume depletion related to vomiting and diarrhea. Phase IV refers to a decrescendo phase, which is a self limiting phase for untreated abdominal pain
Authors: Shivangi T Kothari; Anish M Shah; Deviprasad Botu; Robert Spira; Robert Greenblatt; Joseph Depasquale Journal: J Med Case Rep Date: 2011-02-14