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Literature DB >> 21931924

Synthesis and activity of the archazolid western hemisphere.

Ann B Tran¹, Geoffrey C Melly, Ryan Doucette, Brook Ashcraft, Leanne J Sebren, Nathan Havko, Jeffery C Young, Gregory W O'Neil.

Abstract

A convergent and scalable synthesis of the archazolid western hemisphere has been completed. The V-ATPase inhibitory activity of this compound along with a previously prepared eastern domain was then tested using a convenient Arabidopsis-based V-ATPase assay.

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Year: 2011 PMID： 21931924 DOI： 10.1039/c1ob06446k

Source DB: PubMed Journal: Org Biomol Chem ISSN： 1477-0520 Impact factor: 3.876

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Cited

6 in total

1. Revealing the macromolecular targets of complex natural products.

Authors: Daniel Reker; Anna M Perna; Tiago Rodrigues; Petra Schneider; Michael Reutlinger; Bettina Mönch; Andreas Koeberle; Christina Lamers; Matthias Gabler; Heinrich Steinmetz; Rolf Müller; Manfred Schubert-Zsilavecz; Oliver Werz; Gisbert Schneider
Journal: Nat Chem Date: 2014-11-02 Impact factor: 24.427

Synthesis and activity of the archazolid western hemisphere.

1. Revealing the macromolecular targets of complex natural products.

2. Synthesis of a C₁-C₂₃ fragment of the archazolids and evidence for V-ATPase but not COX inhibitory activity.

3. Synthesis of the C₁-C₁₇ fragment of the archazolids by complex cis-homodimer cross metathesis.

Review 4. Total syntheses of the archazolids: an emerging class of novel anticancer drugs.

5. Suzuki coupling-based synthesis of VATPase inhibitor archazolid natural product derived fragments.

Review 6. Design and Synthesis of Simplified Polyketide Analogs: New Modalities beyond the Rule of 5.

Synthesis and activity of the archazolid western hemisphere.

1. Revealing the macromolecular targets of complex natural products.

2. Synthesis of a C1-C23 fragment of the archazolids and evidence for V-ATPase but not COX inhibitory activity.

3. Synthesis of the C1-C17 fragment of the archazolids by complex cis-homodimer cross metathesis.

Review 4. Total syntheses of the archazolids: an emerging class of novel anticancer drugs.

5. Suzuki coupling-based synthesis of VATPase inhibitor archazolid natural product derived fragments.

Review 6. Design and Synthesis of Simplified Polyketide Analogs: New Modalities beyond the Rule of 5.

2. Synthesis of a C₁-C₂₃ fragment of the archazolids and evidence for V-ATPase but not COX inhibitory activity.

3. Synthesis of the C₁-C₁₇ fragment of the archazolids by complex cis-homodimer cross metathesis.