Literature DB >> 21930343

Efficacy and safety of intraoperative radiotherapy in breast cancer: a systematic review.

A Ruano-Ravina1, P Cantero-Muñoz, A Eraso Urién.   

Abstract

The objective of this study is to assess the efficacy and safety of intraoperative radiotherapy (IORT) for early breast cancer through a systematic review. Fifteen studies met the inclusion criteria. Most studies assessed the combined treatment with IORT (10-24Gy) and external beam radiotherapy (EBRT) (45-50Gy) on early stage breast cancer (T(0-2)). Local control was over 95% for 1 and 4years of follow-up and the 5-year overall survival was 99%. The TARGIT-A study found a similar survival comparing IORT with standard treatment. The incidence of acute and chronic complications was scarce. IORT is well tolerated by patients and acute and late toxicities are low. There are no differences in survival for IORT treated patients versus standard treatment.
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

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Year:  2011        PMID： 21930343     DOI： 10.1016/j.canlet.2011.08.020

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  8 in total

Review 1.  Effects of radiation and chemotherapy on adipose stem cells: Implications for use in fat grafting in cancer patients.

Authors:  Rebecca Platoff; Miguel A Villalobos; Ashleigh Rapp Hagaman; Yuan Liu; Martha Matthews; Michael E DiSanto; Jeffrey P Carpenter; Ping Zhang
Journal:  World J Stem Cells       Date:  2021-08-26       Impact factor: 5.247

2.  Intraoperative radiation therapy delivered prior to lumpectomy for early-stage breast cancer: a single institution study.

Authors:  Wei Yu; Zhi Lin; Zhong-Jian Ju; Xi-Ru Li; Yan-Jun Zhang; Qing-Long Kong; Han-Shun Gong; Jian-Dong Wang; Lin Ma
Journal:  Am J Cancer Res       Date:  2015-06-15       Impact factor: 6.166

Review 3.  Intraoperative radiotherapy for breast cancer: the lasting effects of a fleeting treatment.

Authors:  Harriet B Eldredge-Hindy; Anne L Rosenberg; Nicole L Simone
Journal:  Int J Breast Cancer       Date:  2014-08-10

4.  TGF-β1 Is Present at High Levels in Wound Fluid from Breast Cancer Patients Immediately Post-Surgery, and Is Not Increased by Intraoperative Radiation Therapy (IORT).

Authors:  Sandra D Scherer; Jochen Bauer; Anja Schmaus; Christian Neumaier; Carsten Herskind; Marlon R Veldwijk; Frederik Wenz; Jonathan P Sleeman
Journal:  PLoS One       Date:  2016-09-02       Impact factor: 3.240

5.  Early Outcome, Cosmetic Result and Tolerability of an IOERT-Boost Prior to Adjuvant Whole-Breast Irradiation.

Authors:  Danny Jazmati; Edwin Bölke; Kati Halfmann; Bálint Tamaskovics; Eugen Ruckhäberle; Tanja Fehm; Jürgen Hoffmann; David Krug; Carolin Nestle Krämling; Stefanie Corradini; Wilfried Budach; Svjetlana Mohrmann; Jan Haussmann; Christiane Matuschek
Journal:  Cancers (Basel)       Date:  2022-07-26       Impact factor: 6.575

6.  Clinical aspects of intraoperative radiotherapy in early breast cancer: short-term complications after IORT in women treated with low energy x-rays.

Authors:  Benjamin Tuschy; Sebastian Berlit; Simone Romero; Elena Sperk; Frederik Wenz; Sven Kehl; Marc Sütterlin
Journal:  Radiat Oncol       Date:  2013-04-22       Impact factor: 3.481

7.  Safety, effectiveness and economic evaluation of intra-operative radiation therapy: a systematic review.

Authors:  Farshad Najafipour; Pejman Hamouzadeh; Jalal Arabloo; Mohammadreza Mobinizadeh; Amir Norouzi
Journal:  Med J Islam Repub Iran       Date:  2015-09-07

8.  Cardiac serum marker alterations after intraoperative radiotherapy with low-energy x-rays in early breast cancer as an indicator of possible cardiac toxicity.

Authors:  Stefan Stefanovic; Sebastian Berlit; Elena Sperk; Frederik Wenz; Christel Weiß; Frederik Trinkmann; Marc Sütterlin; Benjamin Tuschy
Journal:  Strahlenther Onkol       Date:  2020-08-19       Impact factor: 3.621
  8 in total

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