Literature DB >> 21930173

Genetic studies on the ghrelin, growth hormone secretagogue receptor (GHSR) and ghrelin O-acyl transferase (GOAT) genes.

Boyang Liu1, Edwin A Garcia, Márta Korbonits.   

Abstract

Ghrelin is a 28 amino acid peptide hormone that is produced both centrally and peripherally. Regulated by the ghrelin O-acyl transferase enzyme, ghrelin exerts its action through the growth hormone secretagogue receptor, and is implicated in a diverse range of physiological processes. These implications have placed the ghrelin signaling pathway at the center of a large number of candidate gene and genome-wide studies which aim to identify the genetic basis of human heterogeneity. In this review we summarize the available data on the genetic variability of ghrelin, its receptor and its regulatory enzyme, and their association with obesity, stature, type 2 diabetes, cardiovascular disease, eating disorders, and reward seeking behavior.
Copyright © 2011 Elsevier Inc. All rights reserved.

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Year:  2011        PMID： 21930173     DOI： 10.1016/j.peptides.2011.09.006

Source DB:  PubMed          Journal:  Peptides        ISSN： 0196-9781            Impact factor:   3.750


  9 in total

1.  The gut hormone ghrelin partially reverses energy substrate metabolic alterations in the failing heart.

Authors:  Gianfranco Mitacchione; Jeffrey C Powers; Gino Grifoni; Felix Woitek; Amy Lam; Lien Ly; Fabio Settanni; Catherine A Makarewich; Ryan McCormick; Letizia Trovato; Steven R Houser; Riccarda Granata; Fabio A Recchia
Journal:  Circ Heart Fail       Date:  2014-05-22       Impact factor: 8.790

Review 2.  Acylation, a Conductor of Ghrelin Function in Brain Health and Disease.

Authors:  Alanna S Thomas; Martina Sassi; Roberto Angelini; Alwena H Morgan; Jeffrey S Davies
Journal:  Front Physiol       Date:  2022-06-30       Impact factor: 4.755

Review 3.  Ghrelin forms in the modulation of energy balance and metabolism.

Authors:  Gianluca Gortan Cappellari; Rocco Barazzoni
Journal:  Eat Weight Disord       Date:  2018-10-24       Impact factor: 4.652

4.  Ghrelin O-Acyl Transferase in Zebrafish Is an Evolutionarily Conserved Peptide Upregulated During Calorie Restriction.

Authors:  Azadeh Hatef; Roman Yufa; Suraj Unniappan
Journal:  Zebrafish       Date:  2015-07-30       Impact factor: 1.985

5.  A closer look at alcohol-induced changes in the ghrelin system: novel insights from preclinical and clinical data.

Authors:  Sara L Deschaine; Mehdi Farokhnia; Adriana Gregory-Flores; Lia J Zallar; Zhi-Bing You; Hui Sun; Deon M Harvey; Renata C N Marchette; Brendan J Tunstall; Bharath K Mani; Jacob E Moose; Mary R Lee; Eliot Gardner; Fatemeh Akhlaghi; Marisa Roberto; James L Hougland; Jeffrey M Zigman; George F Koob; Leandro F Vendruscolo; Lorenzo Leggio
Journal:  Addict Biol       Date:  2021-04-27       Impact factor: 4.093

Review 6.  Ghrelin.

Authors:  T D Müller; R Nogueiras; M L Andermann; Z B Andrews; S D Anker; J Argente; R L Batterham; S C Benoit; C Y Bowers; F Broglio; F F Casanueva; D D'Alessio; I Depoortere; A Geliebter; E Ghigo; P A Cole; M Cowley; D E Cummings; A Dagher; S Diano; S L Dickson; C Diéguez; R Granata; H J Grill; K Grove; K M Habegger; K Heppner; M L Heiman; L Holsen; B Holst; A Inui; J O Jansson; H Kirchner; M Korbonits; B Laferrère; C W LeRoux; M Lopez; S Morin; M Nakazato; R Nass; D Perez-Tilve; P T Pfluger; T W Schwartz; R J Seeley; M Sleeman; Y Sun; L Sussel; J Tong; M O Thorner; A J van der Lely; L H T van der Ploeg; J M Zigman; M Kojima; K Kangawa; R G Smith; T Horvath; M H Tschöp
Journal:  Mol Metab       Date:  2015-03-21       Impact factor: 7.422

7.  Genetic variation of the growth hormone secretagogue receptor gene is associated with alcohol use disorders identification test scores and smoking.

Authors:  Petra Suchankova; Staffan Nilsson; Bettina von der Pahlen; Pekka Santtila; Kenneth Sandnabba; Ada Johansson; Patrick Jern; Jörgen A Engel; Elisabet Jerlhag
Journal:  Addict Biol       Date:  2015-06-09       Impact factor: 4.280

8.  Ghrelin Stimulates Endothelial Cells Angiogenesis through Extracellular Regulated Protein Kinases (ERK) Signaling Pathway.

Authors:  Jun Wang; Lin He; Bahetiyaer Huwatibieke; Lingchao Liu; He Lan; Jing Zhao; Yin Li; Weizhen Zhang
Journal:  Int J Mol Sci       Date:  2018-08-26       Impact factor: 5.923

9.  Ghrelin reverses ductular reaction and hepatic fibrosis in a rodent model of cholestasis.

Authors:  Anca D Petrescu; Stephanie Grant; Elaina Williams; Gabriel Frampton; Evan H Reinhart; Amy Nguyen; Suyeon An; Matthew McMillin; Sharon DeMorrow
Journal:  Sci Rep       Date:  2020-09-29       Impact factor: 4.379
  9 in total

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