Literature DB >> 21929885

Functional colonic obstruction in an adult as a presenting feature of thymoma.

K Malhotra1, I B Georgiades, J Davies.   

Abstract

Functional colonic obstruction is a colonic motility disorder with a number of causes. One cause is myenteric ganglionitis, which may result from paraneoplastic processes. We present the case of a previously healthy 53-year-old man who presented with a week's history of functional colonic obstruction. A transverse loop colostomy failed to resolve his symptoms and he subsequently underwent an extended right hemicolectomy. Histology demonstrated lymphocytic myenteric ganglionitis that was felt to be of paraneoplastic origin. The patient later developed bilateral ptosis and was diagnosed with ocular myasthenia gravis. Further investigation revealed the presence of a thymoma that was resected, resulting in an improvement to his symptoms. We present this case and a review of the literature to illustrate the importance of seeking out a paraneoplastic cause for functional colonic obstruction in adults as early resection of the tumour may help alleviate symptoms and avoid bowel surgery.

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Year:  2011        PMID: 21929885      PMCID: PMC5827056          DOI: 10.1308/147870811X589588

Source DB:  PubMed          Journal:  Ann R Coll Surg Engl        ISSN: 0035-8843            Impact factor:   1.891


  5 in total

1.  Intestinal pseudo-obstruction as a paraneoplastic manifestation of malignant thymoma.

Authors:  D Kulling; C E Reed; G N Verne; P B Cotton; P R Tarnasky
Journal:  Am J Gastroenterol       Date:  1997-09       Impact factor: 10.864

2.  Intestinal pseudo-obstruction as initial presentation of thymoma.

Authors:  C P Musthafa; Ahsan Moosa; P A Chandrashekharan; R Nandakumar; A V Narayanan; V Balakrishnan
Journal:  Indian J Gastroenterol       Date:  2006 Sep-Oct

3.  Intestinal pseudo-obstruction, myasthenia gravis, and thymoma.

Authors:  N E Anderson; D O Hutchinson; G J Nicholson; F Aitcheson; J M Nixon
Journal:  Neurology       Date:  1996-10       Impact factor: 9.910

Review 4.  Inflammatory neuropathies of the enteric nervous system.

Authors:  Roberto De Giorgio; Stefania Guerrini; Giovanni Barbara; Vincenzo Stanghellini; Fabrizio De Ponti; Roberto Corinaldesi; Peter L Moses; Keith A Sharkey; Gary M Mawe
Journal:  Gastroenterology       Date:  2004-06       Impact factor: 22.682

5.  Paraneoplastic syndromes in thymoma: an immunological perspective.

Authors:  Robert P Nelson; Robert M Pascuzzi
Journal:  Curr Treat Options Oncol       Date:  2009-02-06
  5 in total
  3 in total

1.  Lymphocytic ganglionitis leading to megacolon in lymphocyte-rich glioblastoma.

Authors:  Jared T Ahrendsen; Kevin R Anderson; Matthew P Anderson
Journal:  J Neuroimmunol       Date:  2019-10-19       Impact factor: 3.478

2.  Adhesive ileus complicating recurrent intestinal pseudo-obstruction in a patient with myasthenia gravis.

Authors:  Charalampos Seretis; Fotios Seretis; George Gemenetzis; Stavros Gourgiotis; Emmanuel Lagoudianakis; Apostolos Pappas; Dimitrios Keramidaris; Nikolaos Salemis
Journal:  Case Rep Gastroenterol       Date:  2012-06-26

3.  Chronic Intestinal Pseudo-Obstruction Due to Incidentally Found Thymoma.

Authors:  Daniel Castaneda; Rafael Miret; Rajaganesh Rajagopalan; Michael Castillo; Adalberto Gonzalez; Fernando Castro
Journal:  ACG Case Rep J       Date:  2021-06-02
  3 in total

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