| Literature DB >> 21929885 |
K Malhotra1, I B Georgiades, J Davies.
Abstract
Functional colonic obstruction is a colonic motility disorder with a number of causes. One cause is myenteric ganglionitis, which may result from paraneoplastic processes. We present the case of a previously healthy 53-year-old man who presented with a week's history of functional colonic obstruction. A transverse loop colostomy failed to resolve his symptoms and he subsequently underwent an extended right hemicolectomy. Histology demonstrated lymphocytic myenteric ganglionitis that was felt to be of paraneoplastic origin. The patient later developed bilateral ptosis and was diagnosed with ocular myasthenia gravis. Further investigation revealed the presence of a thymoma that was resected, resulting in an improvement to his symptoms. We present this case and a review of the literature to illustrate the importance of seeking out a paraneoplastic cause for functional colonic obstruction in adults as early resection of the tumour may help alleviate symptoms and avoid bowel surgery.Entities:
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Year: 2011 PMID: 21929885 PMCID: PMC5827056 DOI: 10.1308/147870811X589588
Source DB: PubMed Journal: Ann R Coll Surg Engl ISSN: 0035-8843 Impact factor: 1.891