AIMS/HYPOTHESIS: Loss of weight and body fat are major targets in lifestyle interventions to prevent diabetes. In the brain, insulin modulates eating behaviour and weight control, resulting in a negative energy balance. This study aimed to test whether cerebral insulin sensitivity facilitates reduction of body weight and body fat by lifestyle intervention in humans. METHODS: The study was performed as an additional arm of the TUebingen Lifestyle Intervention Program (TULIP). In 28 non-diabetic individuals (14 female/14 male; mean ± SE age 42 ± 2 years; mean ± SE BMI 29.9 ± 0.8 kg/m²), we measured cerebrocortical insulin sensitivity by using magnetoencephalography before lifestyle intervention. Total and visceral fat were measured by using MRI at baseline and after 9 months and 2 years of lifestyle intervention. RESULTS: Insulin-stimulated cerebrocortical theta activity at baseline correlated with a reduction in total adipose tissue (r = -0.59, p = 0.014) and visceral adipose tissue (r = -0.76, p = 0.001) after 9 months of lifestyle intervention, accompanied by a statistical trend for reduction in body weight change (r = -0.37, p = 0.069). Similar results were obtained after 2 years. CONCLUSIONS/ INTERPRETATION: Our results suggest that high insulin sensitivity of the human brain facilitates loss of body weight and body fat during lifestyle intervention.
RCT Entities:
AIMS/HYPOTHESIS: Loss of weight and body fat are major targets in lifestyle interventions to prevent diabetes. In the brain, insulin modulates eating behaviour and weight control, resulting in a negative energy balance. This study aimed to test whether cerebral insulin sensitivity facilitates reduction of body weight and body fat by lifestyle intervention in humans. METHODS: The study was performed as an additional arm of the TUebingen Lifestyle Intervention Program (TULIP). In 28 non-diabetic individuals (14 female/14 male; mean ± SE age 42 ± 2 years; mean ± SE BMI 29.9 ± 0.8 kg/m²), we measured cerebrocortical insulin sensitivity by using magnetoencephalography before lifestyle intervention. Total and visceral fat were measured by using MRI at baseline and after 9 months and 2 years of lifestyle intervention. RESULTS:Insulin-stimulated cerebrocortical theta activity at baseline correlated with a reduction in total adipose tissue (r = -0.59, p = 0.014) and visceral adipose tissue (r = -0.76, p = 0.001) after 9 months of lifestyle intervention, accompanied by a statistical trend for reduction in body weight change (r = -0.37, p = 0.069). Similar results were obtained after 2 years. CONCLUSIONS/ INTERPRETATION: Our results suggest that high insulin sensitivity of the human brain facilitates loss of body weight and body fat during lifestyle intervention.
Authors: Otto Tschritter; Hubert Preissl; Anita M Hennige; Michael Stumvoll; Katarina Porubska; Rebekka Frost; Hannah Marx; Benjamin Klösel; Werner Lutzenberger; Niels Birbaumer; Hans-Ulrich Häring; Andreas Fritsche Journal: Proc Natl Acad Sci U S A Date: 2006-07-28 Impact factor: 11.205
Authors: S Schäfer; K Kantartzis; J Machann; C Venter; A Niess; F Schick; F Machicao; H-U Häring; A Fritsche; N Stefan Journal: Eur J Clin Invest Date: 2007-07 Impact factor: 4.686
Authors: A M Hennige; T Sartorius; S Z Lutz; O Tschritter; H Preissl; S Hopp; A Fritsche; H-G Rammensee; P Ruth; H-U Häring Journal: Diabetologia Date: 2009-09-15 Impact factor: 10.122
Authors: Otto Tschritter; Hubert Preissl; Anita M Hennige; Tina Sartorius; Yuko Grichisch; Norbert Stefan; Martina Guthoff; Stephan Düsing; Jürgen Machann; Erwin Schleicher; Alexander Cegan; Niels Birbaumer; Andreas Fritsche; Hans-Ulrich Häring Journal: J Clin Endocrinol Metab Date: 2009-10-09 Impact factor: 5.958
Authors: Martin Heni; Stephanie Kullmann; Emma Ahlqvist; Robert Wagner; Fausto Machicao; Harald Staiger; Hans-Ulrich Häring; Peter Almgren; Leif C Groop; Dana M Small; Andreas Fritsche; Hubert Preissl Journal: Diabetologia Date: 2016-09-06 Impact factor: 10.122
Authors: Tina Sartorius; Andreas Peter; Martin Heni; Walter Maetzler; Andreas Fritsche; Hans-Ulrich Häring; Anita M Hennige Journal: PLoS One Date: 2015-05-12 Impact factor: 3.240