Literature DB >> 21927800

A new four-way variant t(5;17;15;20)(q33;q12;q22;q11.2) in acute promyelocytic leukemia.

Jun Yamanouchi1, Takaaki Hato2, Toshiyuki Niiya3, Kazuhiro Miyoshi4, Taichi Azuma4, Ikuya Sakai4, Masaki Yasukawa4.   

Abstract

Acute promyelocytic leukemia (APL) is characterized by t(15;17)(q22;q21), which results in the fusion of the promyelocytic leukemia (PML) gene at 15q22 with the retinoic acid alpha-receptor (RARA) at 17q21. We report a patient with APL carrying a new complex variant translocation (5;17;15;20). Spectral karyotyping analysis of bone marrow cells revealed t(5;17;15;20)(q33;q12;q22;q11.2). Fluorescence in situ hybridization with a PML/RARA dual-color DNA probe showed a single fusion signal, and RT-PCR analysis showed PML/RARA fusion transcripts. Complete remission was attained with a course of conventional chemotherapy with all-trans retinoic acid (ATRA). To our knowledge, this is the first report of a four-way translocation of 5q33 and 20q11 involvement in APL.

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Year:  2011        PMID： 21927800     DOI： 10.1007/s12185-011-0929-1

Source DB:  PubMed          Journal:  Int J Hematol        ISSN： 0925-5710            Impact factor:   2.490


  17 in total

Review 1.  Deconstructing a disease: RARalpha, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia.

Authors:  A Melnick; J D Licht
Journal:  Blood       Date:  1999-05-15       Impact factor: 22.113

2.  A complex, four-way variant t(15;17) in acute promyelocytic leukemia.

Authors:  Soo Jin Yoo; Eul-Ju Seo; Jae Hoon Lee; Yiel-Hea Seo; Pil-Whan Park; Jeong-Yeal Ahn
Journal:  Cancer Genet Cytogenet       Date:  2006-06

Review 3.  Myeloproliferative disorders with translocations of chromosome 5q31-35: role of the platelet-derived growth factor receptor Beta.

Authors:  E Joanna Steer; Nicholas C P Cross
Journal:  Acta Haematol       Date:  2002       Impact factor: 2.195

4.  15/17 translocation, a consistent chromosomal change in acute promyelocytic leukaemia.

Authors:  J D Rowley; H M Golomb; C Dougherty
Journal:  Lancet       Date:  1977-03-05       Impact factor: 79.321

5.  Fusion of retinoic acid receptor alpha to NuMA, the nuclear mitotic apparatus protein, by a variant translocation in acute promyelocytic leukaemia.

Authors:  R A Wells; C Catzavelos; S Kamel-Reid
Journal:  Nat Genet       Date:  1997-09       Impact factor: 38.330

Review 6.  A new complex variant t(4;15;17) in acute promyelocytic leukemia: fluorescence in situ hybridization confirmation and literature review.

Authors:  S Liu; Q Li; W Pang; L Bo; S Qin; X Liu; Q Teng; L Qian; J Wang
Journal:  Cancer Genet Cytogenet       Date:  2001-10-01

7.  The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin-retinoic acid receptor fusion.

Authors:  R L Redner; E A Rush; S Faas; W A Rudert; S J Corey
Journal:  Blood       Date:  1996-02-01       Impact factor: 22.113

8.  A PML/retinoic acid receptor alpha fusion transcript is constantly detected by RNA-based polymerase chain reaction in acute promyelocytic leukemia.

Authors:  S Castaigne; N Balitrand; H de Thé; A Dejean; L Degos; C Chomienne
Journal:  Blood       Date:  1992-06-15       Impact factor: 22.113

9.  Novel translocations that disrupt the platelet-derived growth factor receptor beta (PDGFRB) gene in BCR-ABL-negative chronic myeloproliferative disorders.

Authors:  E Joanna Baxter; Shashikant Kulkarni; José-Luis Vizmanos; Rina Jaju; Giovanni Martinelli; Nicoletta Testoni; George Hughes; Zoryana Salamanchuk; Maria José Calasanz; Idoya Lahortiga; Christopher F Pocock; Raymond Dang; Carrie Fidler; James S Wainscoat; Jacqueline Boultwood; Nicholas C P Cross
Journal:  Br J Haematol       Date:  2003-01       Impact factor: 6.998

10.  Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia.

Authors:  S J Chen; A Zelent; J H Tong; H Q Yu; Z Y Wang; J Derré; R Berger; S Waxman; Z Chen
Journal:  J Clin Invest       Date:  1993-05       Impact factor: 14.808
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  5 in total

1.  Microgranular variant of acute promyelocytic leukemia with der(17) ins(17;15): A case report and review of the literature.

Authors:  Hongzai Guan; Jing Liu; Xiaofang Guo; Chunmei Wu; Huawei Yu
Journal:  Exp Ther Med       Date:  2015-06-18       Impact factor: 2.447

2.  High-Risk Microgranular Acute Promyelocytic Leukemia with a Five-Way Complex Translocation Involving PML-RARA.

Authors:  Benjamin Powers; Diane Persons; Deepthi Rao; Janet Woodroof; Tara L Lin
Journal:  Case Rep Hematol       Date:  2015-01-26

Review 3.  Atypical Rearrangements in APL-Like Acute Myeloid Leukemias: Molecular Characterization and Prognosis.

Authors:  Luca Guarnera; Tiziana Ottone; Emiliano Fabiani; Mariadomenica Divona; Arianna Savi; Serena Travaglini; Giulia Falconi; Paola Panetta; Maria Cristina Rapanotti; Maria Teresa Voso
Journal:  Front Oncol       Date:  2022-04-12       Impact factor: 5.738

4.  Early mortality in acute promyelocytic leukemia: Potential predictors.

Authors:  Can Chen; Xilian Huang; Kaile Wang; Kuang Chen; Danquan Gao; Shenxian Qian
Journal:  Oncol Lett       Date:  2018-01-24       Impact factor: 2.967

Review 5.  Cryptic t(15;17) acute promyelocytic leukemia with a karyotype of add(11)(p15) and t(13,20)- A case report with a literature review.

Authors:  Siyu Gu; Jie Zi; Jinlong Ma; Zheng Ge
Journal:  Bosn J Basic Med Sci       Date:  2021-04-01       Impact factor: 3.363
  5 in total

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