| Literature DB >> 21927797 |
Noah P Tu1, Jill E Hochlowski, Stevan W Djuric.
Abstract
We present a study on ultrasound-promoted click chemistry reactions in a meso-flow reactor synthesis system with a copper reactor and a custom sonication piezoelectric transducer. Copper catalyzed Huisgen 1,3-dipolar cycloadditions were studied in flow with this system. Our results demonstrate that 1,4-disubstituted 1,2,3-triazole products can be generated at low temperatures and with short reaction time in good yield, due to the rate enhancement effect of sonication.Entities:
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Year: 2011 PMID： 21927797 DOI： 10.1007/s11030-011-9331-4
Source DB: PubMed Journal: Mol Divers ISSN： 1381-1991 Impact factor: 2.943