Literature DB >> 21927513

An unexpected synthesis of 3,5-diaryl-1,2,4-thiadiazoles from thiobenzamides and methyl bromocyanoacetate.

Abdelrahman S Mayhoub1, Evgeny Kiselev, Mark Cushman.   

Abstract

Aryl thioamides undergo a very rapid condensation in the presence of methyl bromocyanoacetate to provide quantitative yields of 3,5-diaryl-1,2,4-thiadiazoles with easy work-up and a high degree of product purity. The method can be scaled up with no loss in efficiency.

Entities:  

Year:  2011        PMID： 21927513      PMCID： PMC3171967          DOI： 10.1016/j.tetlet.2011.07.068

Source DB:  PubMed          Journal:  Tetrahedron Lett        ISSN： 0040-4039            Impact factor:   2.415


  2 in total

1.  Iodoxolone-based hypervalent iodine reagents.

Authors:  Azhar-ul-Haq A Shah; Zulfiqar A Khan; Naila Choudhary; Christine Lohölter; Sascha Schäfer; Guillaume P L Marie; Umar Farooq; Bernhard Witulski; Thomas Wirth
Journal:  Org Lett       Date:  2009-08-20       Impact factor: 6.005

2.  Design, synthesis, and biological evaluation of antiviral agents targeting flavivirus envelope proteins.

Authors:  Ze Li; Mansoora Khaliq; Zhigang Zhou; Carol Beth Post; Richard J Kuhn; Mark Cushman
Journal:  J Med Chem       Date:  2008-07-09       Impact factor: 7.446
  2 in total
  2 in total

1.  Optimization of thiazole analogues of resveratrol for induction of NAD(P)H:quinone reductase 1 (QR1).

Authors:  Abdelrahman S Mayhoub; Laura Marler; Tamara P Kondratyuk; Eun-Jung Park; John M Pezzuto; Mark Cushman
Journal:  Bioorg Med Chem       Date:  2012-10-23       Impact factor: 3.641

2.  Amyloid-β probes: Review of structure-activity and brain-kinetics relationships.

Authors:  Todd J Eckroat; Abdelrahman S Mayhoub; Sylvie Garneau-Tsodikova
Journal:  Beilstein J Org Chem       Date:  2013-05-28       Impact factor: 2.883
  2 in total

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