Abdelrahman S Mayhoub1, Evgeny Kiselev, Mark Cushman. 1. Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and the Purdue University Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907.
Abstract
Aryl thioamides undergo a very rapid condensation in the presence of methyl bromocyanoacetate to provide quantitative yields of 3,5-diaryl-1,2,4-thiadiazoles with easy work-up and a high degree of product purity. The method can be scaled up with no loss in efficiency.
Aryl thioamides undergo a very rapid condensation in the presence of n class="Chemical">methyl bromocyanoacetate to provide quantitative yields of 3,5-diaryl-1,2,4-thiadiazoles with easy work-up and a high degree of product purity. The method can be scaled up with no loss in efficiency.
Authors: Azhar-ul-Haq A Shah; Zulfiqar A Khan; Naila Choudhary; Christine Lohölter; Sascha Schäfer; Guillaume P L Marie; Umar Farooq; Bernhard Witulski; Thomas Wirth Journal: Org Lett Date: 2009-08-20 Impact factor: 6.005
Authors: Abdelrahman S Mayhoub; Laura Marler; Tamara P Kondratyuk; Eun-Jung Park; John M Pezzuto; Mark Cushman Journal: Bioorg Med Chem Date: 2012-10-23 Impact factor: 3.641