Literature DB >> 2192711

Production of granulocyte/macrophage colony-stimulating factor by cultured astrocytes.

K Ohno1, A Suzumura, M Sawada, T Marunouchi.   

Abstract

We investigated the production of interleukin-3 (IL-3)-like factor by murine astrocytes. Supernatants from lipopolysaccharide (LPS)-stimulated astrocytes induced proliferation of IC-2, an IL-3- and granulocyte/macrophage colony-stimulating factor (GM-CSF)-dependent cell line. This activity was completely neutralized by the antibody against GM-CSF but not by the anti-IL-3 monoclonal antibody. Northern blot analysis revealed the expression of GM-CSF mRNA, but not of IL-3 mRNA, in cultured astrocytes. These results indicate that with proper stimuli murine astrocytes produce GM-CSF.

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Year:  1990        PMID： 2192711     DOI： 10.1016/0006-291x(90)90390-9

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  9 in total

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Authors:  A Suzumura; M Sawada; T Marunouchi
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7.  Regulation of astrocyte proliferation by prostaglandin E2 and the alpha subtype of protein kinase C.

Authors:  M Sawada; A Suzumura; K Ohno; T Marunouchi
Journal:  Brain Res       Date:  1993-06-04       Impact factor: 3.252

8.  Cytokine network in the central nervous system and its roles in growth and differentiation of glial and neuronal cells.

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9.  Interleukin-4 induces proliferation and activation of microglia but suppresses their induction of class II major histocompatibility complex antigen expression.

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  9 in total

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