Literature DB >> 21926994

A natural prodrug activation mechanism in nonribosomal peptide synthesis.

Daniela Reimer1, Klaas M Pos, Marco Thines, Peter Grün, Helge B Bode.   

Abstract

We have identified a new mechanism for the cleavage and activation of nonribosomally made peptides and peptide-polyketide hybrids that are apparently operational in several different bacteria. This process includes the cleavage of a precursor molecule by a membrane-bound and D-asparagine-specific peptidase, as shown here in the biosynthesis of the antibiotic xenocoumacin from Xenorhabdus nematophila.

Entities:  

Mesh：

Substances：

Year:  2011        PMID： 21926994     DOI： 10.1038/nchembio.688

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


  21 in total

1.  Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions.

Authors:  E Krissinel; K Henrick
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2004-11-26

Review 2.  Biosynthesis of nonribosomal peptides1.

Authors:  Robert Finking; Mohamed A Marahiel
Journal:  Annu Rev Microbiol       Date:  2004       Impact factor: 15.500

Review 3.  Type 1 protein secretion in bacteria, the ABC-transporter dependent pathway (review).

Authors:  I Barry Holland; Lutz Schmitt; Joanne Young
Journal:  Mol Membr Biol       Date:  2005 Jan-Apr       Impact factor: 2.857

4.  Protein structure prediction on the Web: a case study using the Phyre server.

Authors:  Lawrence A Kelley; Michael J E Sternberg
Journal:  Nat Protoc       Date:  2009       Impact factor: 13.491

5.  Albumins and their processing machinery are hijacked for cyclic peptides in sunflower.

Authors:  Joshua S Mylne; Michelle L Colgrave; Norelle L Daly; Aurelie H Chanson; Alysha G Elliott; Emily J McCallum; Alun Jones; David J Craik
Journal:  Nat Chem Biol       Date:  2011-03-20       Impact factor: 15.040

Review 6.  Type I signal peptidase: an overview.

Authors:  Renu Tuteja
Journal:  Arch Biochem Biophys       Date:  2005-09-15       Impact factor: 4.013

7.  Isolation of 8'-phosphate ester derivatives of amicoumacins: structure-activity relationship of hydroxy amino acid moiety.

Authors:  Makoto Hashimoto; Takaaki Taguchi; Satoshi Nishida; Kouji Ueno; Kaio Koizumi; Masaki Aburada; Koji Ichinose
Journal:  J Antibiot (Tokyo)       Date:  2007-12       Impact factor: 2.649

Review 8.  They've got a ticket to ride: Xenorhabdus nematophila-Steinernema carpocapsae symbiosis.

Authors:  Heidi Goodrich-Blair
Journal:  Curr Opin Microbiol       Date:  2007-06-05       Impact factor: 7.934

Review 9.  Friend and foe: the two faces of Xenorhabdus nematophila.

Authors:  Erin E Herbert; Heidi Goodrich-Blair
Journal:  Nat Rev Microbiol       Date:  2007-08       Impact factor: 60.633

Review 10.  Lantibiotics: peptides of diverse structure and function.

Authors:  Joanne M Willey; Wilfred A van der Donk
Journal:  Annu Rev Microbiol       Date:  2007       Impact factor: 15.500
View more
  36 in total

Review 1.  The phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for life.

Authors:  Joris Beld; Eva C Sonnenschein; Christopher R Vickery; Joseph P Noel; Michael D Burkart
Journal:  Nat Prod Rep       Date:  2014-01       Impact factor: 13.423

Review 2.  Merging chemical ecology with bacterial genome mining for secondary metabolite discovery.

Authors:  Maria I Vizcaino; Xun Guo; Jason M Crawford
Journal:  J Ind Microbiol Biotechnol       Date:  2013-10-15       Impact factor: 3.346

3.  Low-molecular-weight metabolites secreted by Paenibacillus larvae as potential virulence factors of American foulbrood.

Authors:  Hedwig-Annabell Schild; Sebastian W Fuchs; Helge B Bode; Bernd Grünewald
Journal:  Appl Environ Microbiol       Date:  2014-02-07       Impact factor: 4.792

4.  Bacterial biosynthesis and maturation of the didemnin anti-cancer agents.

Authors:  Ying Xu; Roland D Kersten; Sang-Jip Nam; Liang Lu; Abdulaziz M Al-Suwailem; Huajun Zheng; William Fenical; Pieter C Dorrestein; Bradley S Moore; Pei-Yuan Qian
Journal:  J Am Chem Soc       Date:  2012-04-06       Impact factor: 15.419

5.  Pyrones as bacterial signaling molecules.

Authors:  Alexander O Brachmann; Sophie Brameyer; Darko Kresovic; Ivana Hitkova; Yannick Kopp; Christian Manske; Karin Schubert; Helge B Bode; Ralf Heermann
Journal:  Nat Chem Biol       Date:  2013-07-14       Impact factor: 15.040

6.  In Vitro Characterization of the Colibactin-Activating Peptidase ClbP Enables Development of a Fluorogenic Activity Probe.

Authors:  Matthew R Volpe; Matthew R Wilson; Carolyn A Brotherton; Ethan S Winter; Sheila E Johnson; Emily P Balskus
Journal:  ACS Chem Biol       Date:  2019-05-13       Impact factor: 5.100

7.  Non-ribosomal propeptide precursor in nocardicin A biosynthesis predicted from adenylation domain specificity dependent on the MbtH family protein NocI.

Authors:  Jeanne M Davidsen; David M Bartley; Craig A Townsend
Journal:  J Am Chem Soc       Date:  2013-01-18       Impact factor: 15.419

8.  ω-Azido fatty acids as probes to detect fatty acid biosynthesis, degradation, and modification.

Authors:  Alexander J Pérez; Helge B Bode
Journal:  J Lipid Res       Date:  2014-07-10       Impact factor: 5.922

Review 9.  Gut microbiota imbalance and colorectal cancer.

Authors:  Johan Gagnière; Jennifer Raisch; Julie Veziant; Nicolas Barnich; Richard Bonnet; Emmanuel Buc; Marie-Agnès Bringer; Denis Pezet; Mathilde Bonnet
Journal:  World J Gastroenterol       Date:  2016-01-14       Impact factor: 5.742

Review 10.  Crossroads of Antibiotic Resistance and Biosynthesis.

Authors:  Timothy A Wencewicz
Journal:  J Mol Biol       Date:  2019-07-06       Impact factor: 5.469
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.