MADM gives new insights into gliomagenesis.

In their recent paper, Liu et al. (2011) make use of an elegant genetic mouse model to study the formation of malignant brain tumors. Their findings add strong support to the growing body of evidence from several labs showing that some gliomas arise from oligodendrocyte precursor cells (OPCs). They also provide new insights, and raise new questions, regarding where, when, and how malignant gliomas form.