BACKGROUND: There are few population-based data regarding gender differences in signs and symptoms of acute ischemic stroke, and previously reported data have been inconsistent and conflicting. OBJECTIVE: The goal of this study was to address the gender differences of the presenting signs and symptoms of acute ischemic stroke in a population-based study. METHODS: All patients with first ischemic stroke occurring between 1985 and 1989 were identified; subjects were residents of Rochester, Minnesota. Signs and symptoms were collected via review of comprehensive medical records. Differences were identified using the Pearson χ(2) test. RESULTS: A total of 449 cases of first ischemic stroke were identified; 268 (60%) were women. Symptoms at ischemic stroke presentation differed between men and women. Women more commonly presented with generalized weakness (P = 0.005) and mental status change (P = 0.0001). Men more commonly presented with paresthesia (P = 0.003), ataxia (P = 0.006), and double vision (P = 0.005). Signs at ischemic stroke presentation differed between men and women. Men more commonly presented with nystagmus (P = 0.002) on examination. Significant trends were that women more commonly presented with fatigue (P = 0.02), disorientation (P = 0.04), and fever (P = 0.02), whereas men more commonly presented with sensory abnormalities (P = 0.02). CONCLUSIONS: There were gender differences in signs and symptoms at presentation of ischemic stroke in these study patients. In addition to selected focal symptoms, women more commonly presented with diffuse symptoms of generalized weakness, fatigue, disorientation, and mental status change.
BACKGROUND: There are few population-based data regarding gender differences in signs and symptoms of acute ischemic stroke, and previously reported data have been inconsistent and conflicting. OBJECTIVE: The goal of this study was to address the gender differences of the presenting signs and symptoms of acute ischemic stroke in a population-based study. METHODS: All patients with first ischemic stroke occurring between 1985 and 1989 were identified; subjects were residents of Rochester, Minnesota. Signs and symptoms were collected via review of comprehensive medical records. Differences were identified using the Pearson χ(2) test. RESULTS: A total of 449 cases of first ischemic stroke were identified; 268 (60%) were women. Symptoms at ischemic stroke presentation differed between men and women. Women more commonly presented with generalized weakness (P = 0.005) and mental status change (P = 0.0001). Men more commonly presented with paresthesia (P = 0.003), ataxia (P = 0.006), and double vision (P = 0.005). Signs at ischemic stroke presentation differed between men and women. Men more commonly presented with nystagmus (P = 0.002) on examination. Significant trends were that women more commonly presented with fatigue (P = 0.02), disorientation (P = 0.04), and fever (P = 0.02), whereas men more commonly presented with sensory abnormalities (P = 0.02). CONCLUSIONS: There were gender differences in signs and symptoms at presentation of ischemic stroke in these study patients. In addition to selected focal symptoms, women more commonly presented with diffuse symptoms of generalized weakness, fatigue, disorientation, and mental status change.
Authors: Antonio Di Carlo; Maria Lamassa; Marzia Baldereschi; Giovanni Pracucci; Anna Maria Basile; Charles D A Wolfe; Maurice Giroud; Anthony Rudd; Augusto Ghetti; Domenico Inzitari Journal: Stroke Date: 2003-04-10 Impact factor: 7.914
Authors: Lynda D Lisabeth; Devin L Brown; Rebecca Hughes; Jennifer J Majersik; Lewis B Morgenstern Journal: Stroke Date: 2009-02-19 Impact factor: 7.914
Authors: Prasanthi Govindarajan; Benjamin T Friedman; James Q Delgadillo; David Ghilarducci; Lawrence J Cook; Barbara Grimes; Charles E McCulloch; S Claiborne Johnston Journal: Acad Emerg Med Date: 2015-02-25 Impact factor: 3.451
Authors: Cheryl D Bushnell; Seemant Chaturvedi; Kathy R Gage; Paco S Herson; Patricia D Hurn; Monik C Jiménez; Steven J Kittner; Tracy E Madsen; Louise D McCullough; Mollie McDermott; Mathew J Reeves; Tatjana Rundek Journal: J Cereb Blood Flow Metab Date: 2018-08-17 Impact factor: 6.200
Authors: Kathryn M Rexrode; Tracy E Madsen; Amy Y X Yu; Cheryl Carcel; Judith H Lichtman; Eliza C Miller Journal: Circ Res Date: 2022-02-17 Impact factor: 17.367
Authors: Anna K Bonkhoff; Markus D Schirmer; Martin Bretzner; Sungmin Hong; Robert W Regenhardt; Mikael Brudfors; Kathleen L Donahue; Marco J Nardin; Adrian V Dalca; Anne-Katrin Giese; Mark R Etherton; Brandon L Hancock; Steven J T Mocking; Elissa C McIntosh; John Attia; Oscar R Benavente; Stephen Bevan; John W Cole; Amanda Donatti; Christoph J Griessenauer; Laura Heitsch; Lukas Holmegaard; Katarina Jood; Jordi Jimenez-Conde; Steven J Kittner; Robin Lemmens; Christopher R Levi; Caitrin W McDonough; James F Meschia; Chia-Ling Phuah; Arndt Rolfs; Stefan Ropele; Jonathan Rosand; Jaume Roquer; Tatjana Rundek; Ralph L Sacco; Reinhold Schmidt; Pankaj Sharma; Agnieszka Slowik; Martin Söderholm; Alessandro Sousa; Tara M Stanne; Daniel Strbian; Turgut Tatlisumak; Vincent Thijs; Achala Vagal; Johan Wasselius; Daniel Woo; Ramin Zand; Patrick F McArdle; Bradford B Worrall; Christina Jern; Arne G Lindgren; Jane Maguire; Danilo Bzdok; Ona Wu; Natalia S Rost Journal: Nat Commun Date: 2021-06-02 Impact factor: 14.919
Authors: Sukjin Koh; Andrew S Gordon; Christopher Wienberg; Sara O Sood; Stephanie Morley; Deborah M Burke Journal: J Med Internet Res Date: 2014-03-19 Impact factor: 5.428