BACKGROUND: The amygdala is involved in the emotional responses to fear including anxiety and heightened pain reporting. In a rodent model, bilateral activation of the central amygdala (CeA) with corticosterone (CORT) produces anxiety-like behavior, somatic allodynia and visceral hypersensitivity. Although hemisphere-specific processing differences between the left and right amygdala have been reported, it remains unclear whether the right or left CeA is involved in the production of anxiety-like behavior, and abnormal somatic and visceral perception. The goal of the present study was to investigate the hypothesis that lateralized corticoid-mediated mechanisms in the CeA produce anxiety as well as abnormal pain perception. METHODS: Anesthetized rats received stereotaxic implants of cholesterol (Chol; 30 μg) or CORT (30 μg) micropellets onto the left, right or both dorsal margins of the CeA. Following implantation (5-7 days), anxiety-like behavior was assessed on the elevated plus-maze (EPM), somatic allodynia was measured using Von Frey filaments, and visceral sensitivity was quantified as a visceromotor response (VMR) to colorectal distention (CRD) at 0-60 mmHg. RESULTS: Unilateral implants of CORT onto either the left or right CeA produced anxiety-like behavior and somatic allodynia. However, our data illustrated that the bilateral placement of CORT onto the CeA was required to increase visceral sensitivity. CONCLUSION: These results provide evidence that there is no hemispheric lateralization of the CeA involved in corticoid-mediated anxiety-like behavior and heightened pain reporting. Published by Elsevier Inc.
BACKGROUND: The amygdala is involved in the emotional responses to fear including anxiety and heightened pain reporting. In a rodent model, bilateral activation of the central amygdala (CeA) with corticosterone (CORT) produces anxiety-like behavior, somatic allodynia and visceral hypersensitivity. Although hemisphere-specific processing differences between the left and right amygdala have been reported, it remains unclear whether the right or left CeA is involved in the production of anxiety-like behavior, and abnormal somatic and visceral perception. The goal of the present study was to investigate the hypothesis that lateralized corticoid-mediated mechanisms in the CeA produce anxiety as well as abnormal pain perception. METHODS: Anesthetized rats received stereotaxic implants of cholesterol (Chol; 30 μg) or CORT (30 μg) micropellets onto the left, right or both dorsal margins of the CeA. Following implantation (5-7 days), anxiety-like behavior was assessed on the elevated plus-maze (EPM), somatic allodynia was measured using Von Frey filaments, and visceral sensitivity was quantified as a visceromotor response (VMR) to colorectal distention (CRD) at 0-60 mmHg. RESULTS: Unilateral implants of CORT onto either the left or right CeA produced anxiety-like behavior and somatic allodynia. However, our data illustrated that the bilateral placement of CORT onto the CeA was required to increase visceral sensitivity. CONCLUSION: These results provide evidence that there is no hemispheric lateralization of the CeA involved in corticoid-mediated anxiety-like behavior and heightened pain reporting. Published by Elsevier Inc.
Authors: John R Keltner; Colm G Connolly; Florin Vaida; Mark Jenkinson; Christine Fennema-Notestine; Sarah Archibald; Cherine Akkari; Alexandra Schlein; Jisu Lee; Dongzhe Wang; Sung Kim; Han Li; Austin Rennels; David J Miller; George Kesidis; Donald R Franklin; Chelsea Sanders; Stephanie Corkran; Igor Grant; Gregory G Brown; J Hampton Atkinson; Ronald J Ellis Journal: Pain Med Date: 2017-03-01 Impact factor: 3.750
Authors: Laura E Simons; Eric A Moulton; Clas Linnman; Elizabeth Carpino; Lino Becerra; David Borsook Journal: Hum Brain Mapp Date: 2012-10-25 Impact factor: 5.038
Authors: Charlis Raineki; Emma Sarro; Millie Rincón-Cortés; Rosemarie Perry; Joy Boggs; Colin J Holman; Donald A Wilson; Regina M Sullivan Journal: Neuropsychopharmacology Date: 2014-10-06 Impact factor: 7.853