| Literature DB >> 21925252 |
Patrick Marmorato1, Giacomo Ceccone, Alessandra Gianoncelli, Lorella Pascolo, Jessica Ponti, François Rossi, Murielle Salomé, Burkhard Kaulich, Maya Kiskinova.
Abstract
The effect of the concentration of cobalt ferrite (CoFe(2)O(4)) nanoparticles (NPs) on their intracellular location and distribution has been explored by synchrotron radiation X-ray and fluorescence microscopy (SR-XRF) monitoring the evolution of NPs elemental composition as well. In cells exposed to low concentrations of CoFe(2)O(4) NPs, the NPs preferentially segregate in the perinuclear region preserving their initial chemical content. At concentrations exceeding 500 μM the XRF spectra indicate the presence of Co and Fe also in the nuclear region, accompanied by sensible changes in the cellular morphology. The increase of the Co/Fe ratio measured in the nuclear compartment indicates that above certain concentrations the CoFe(2)O(4) NPs intracellular distribution could be accompanied by biodegradation resulting in Co accumulation in the nucleus.Entities:
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Year: 2011 PMID： 21925252 DOI： 10.1016/j.toxlet.2011.08.026
Source DB: PubMed Journal: Toxicol Lett ISSN： 0378-4274 Impact factor: 4.372