PURPOSE: Sulthiame is an old antiepileptic drug primarily used in a few European countries for the treatment of benign epilepsy of childhood with central temporal spikes. Other studies suggest that it might be effective in children and adults with a range of refractory seizure types. METHODS: A retrospective case note review was undertaken to evaluate the efficacy and safety of sulthiame as adjunctive therapy in children with refractory epilepsies. RESULTS: Twenty patients (10 female) were evaluated, aged 10.7 (range 2.1-17) years. The median duration of treatment with sulthiame was 18 (range 2-37) months. Fifty five percent of patients showed at least a 50% reduction in seizure frequency and two patients were seizure-free at the end of follow-up. Patients with focal seizures responded best. Seven patients reported side effects, leading to withdrawal of the drug in two (10%). CONCLUSION: Sulthiame was reasonably effective and well-tolerated in a heterogeneous group of 20 children with refractory epilepsies. Although an 'old' antiepileptic drug it should be considered in a similar population. 2011 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.
PURPOSE:Sulthiame is an old antiepileptic drug primarily used in a few European countries for the treatment of benign epilepsy of childhood with central temporal spikes. Other studies suggest that it might be effective in children and adults with a range of refractory seizure types. METHODS: A retrospective case note review was undertaken to evaluate the efficacy and safety of sulthiame as adjunctive therapy in children with refractory epilepsies. RESULTS: Twenty patients (10 female) were evaluated, aged 10.7 (range 2.1-17) years. The median duration of treatment with sulthiame was 18 (range 2-37) months. Fifty five percent of patients showed at least a 50% reduction in seizure frequency and two patients were seizure-free at the end of follow-up. Patients with focal seizures responded best. Seven patients reported side effects, leading to withdrawal of the drug in two (10%). CONCLUSION:Sulthiame was reasonably effective and well-tolerated in a heterogeneous group of 20 children with refractory epilepsies. Although an 'old' antiepileptic drug it should be considered in a similar population. 2011 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.
Authors: Yang Hu; Kai Lang; Chaoqun Li; Joseph B Gill; Isaac Kim; Hongjian Lu; Kimberly B Fields; McKenzie Marshall; Qigan Cheng; Xin Cui; Lukasz Wojtas; X Peter Zhang Journal: J Am Chem Soc Date: 2019-11-01 Impact factor: 15.419
Authors: Kateryna O Stepannikova; Bohdan V Vashchenko; Oleksandr O Grygorenko; Marian V Gorichko; Artem Yu Cherepakha; Yurii S Moroz; Yulian M Volovenko; Serhii Zhersh Journal: European J Org Chem Date: 2020-04-07