Literature DB >> 21924901

Acidic triazoles as soluble guanylate cyclase stimulators.

Lee R Roberts1, Paul A Bradley, Mark E Bunnage, Katherine S England, David Fairman, Yvette M Fobian, David N A Fox, Geoff E Gymer, Steven E Heasley, Jerome Molette, Graham L Smith, Michelle A Schmidt, Michael A Tones, Kevin N Dack.   

Abstract

A series of acidic triazoles with activity as soluble guanylate cyclase stimulators is described. Incorporation of the CF(3) triazole improved the overall physicochemical and drug-like properties of the molecule and is exemplified by compound 25.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 21924901     DOI： 10.1016/j.bmcl.2011.08.071

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  YC-1 binding to the β subunit of soluble guanylyl cyclase overcomes allosteric inhibition by the α subunit.

Authors:  Rahul Purohit; Bradley G Fritz; Juliana The; Aaron Issaian; Andrzej Weichsel; Cynthia L David; Eric Campbell; Andrew C Hausrath; Leida Rassouli-Taylor; Elsa D Garcin; Matthew J Gage; William R Montfort
Journal:  Biochemistry       Date:  2013-12-30       Impact factor: 3.162

Review 2.  Structure and Activation of Soluble Guanylyl Cyclase, the Nitric Oxide Sensor.

Authors:  William R Montfort; Jessica A Wales; Andrzej Weichsel
Journal:  Antioxid Redox Signal       Date:  2016-04-26       Impact factor: 8.401

3.  A novel synthetic approach to hydroimidazo[1,5-b]pyridazines by the recyclization of itaconimides and HPLC-HRMS monitoring of the reaction pathway.

Authors:  Dmitry Yu Vandyshev; Khidmet S Shikhaliev; Andrey Yu Potapov; Michael Yu Krysin; Fedor I Zubkov; Lyudmila V Sapronova
Journal:  Beilstein J Org Chem       Date:  2017-11-30       Impact factor: 2.883

4.  Synthesis of imidazo[1,5-a]pyridines via cyclocondensation of 2-(aminomethyl)pyridines with electrophilically activated nitroalkanes.

Authors:  Dmitrii A Aksenov; Nikolai A Arutiunov; Vladimir V Maliuga; Alexander V Aksenov; Michael Rubin
Journal:  Beilstein J Org Chem       Date:  2020-11-26       Impact factor: 2.883
  4 in total

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