Reduced microbial attachment by D-amino acid-inhibited AI-2 and EPS production.

This study investigated the effect of D-tyrosine on microbial attachment to hydrophilic glass and hydrophobic polypropylene surfaces. Results showed that D-tyrosine did not influence microbial growth, ATP and substrate utilization, but significantly inhibited the synthesis of autoinducer-2 (AI-2), eDNA and extracellular polysaccharides and proteins, and subsequently reduced microbial attachment onto glass and polypropylene surfaces was observed. It was shown that D-amino acid would be a non-toxic agent for control of microbial attachment.