Literature DB >> 21924373

Ras trafficking, localization and compartmentalized signalling.

Ian A Prior1, John F Hancock.   

Abstract

Ras proteins are proto-oncogenes that are frequently mutated in human cancers. Three closely related isoforms, HRAS, KRAS and NRAS, are expressed in all cells and have overlapping but distinctive functions. Recent work has revealed how differences between the Ras isoforms in their trafficking, localization and protein-membrane orientation enable signalling specificity to be determined. We review the various strategies used to characterize compartmentalized Ras localization and signalling. Localization is an important contextual modifier of signalling networks and insights from the Ras system are of widespread relevance for researchers interested in signalling initiated from membranes.
Copyright © 2011. Published by Elsevier Ltd.

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Year:  2011        PMID： 21924373      PMCID： PMC3378476          DOI： 10.1016/j.semcdb.2011.09.002

Source DB:  PubMed          Journal:  Semin Cell Dev Biol        ISSN： 1084-9521            Impact factor:   7.727


  115 in total

Review 1.  Regulatory activity of polyunsaturated fatty acids in T-cell signaling.

Authors:  Wooki Kim; Naim A Khan; David N McMurray; Ian A Prior; Naisyin Wang; Robert S Chapkin
Journal:  Prog Lipid Res       Date:  2010-02-20       Impact factor: 16.195

2.  Differential modification of Ras proteins by ubiquitination.

Authors:  Natalia Jura; Elizabeth Scotto-Lavino; Aleksander Sobczyk; Dafna Bar-Sagi
Journal:  Mol Cell       Date:  2006-03-03       Impact factor: 17.970

Review 3.  Ras oncogenes and their downstream targets.

Authors:  Krishnaraj Rajalingam; Ralf Schreck; Ulf R Rapp; Stefan Albert
Journal:  Biochim Biophys Acta       Date:  2007-01-28

4.  Palmitoylation and localisation of RAS isoforms are modulated by the hypervariable linker domain.

Authors:  Alex J Laude; Ian A Prior
Journal:  J Cell Sci       Date:  2008-01-22       Impact factor: 5.285

5.  Live-cell imaging of endogenous Ras-GTP illustrates predominant Ras activation at the plasma membrane.

Authors:  Martin Augsten; Rico Pusch; Christoph Biskup; Knut Rennert; Ute Wittig; Katja Beyer; Alfred Blume; Reinhard Wetzker; Karlheinz Friedrich; Ignacio Rubio
Journal:  EMBO Rep       Date:  2006-01       Impact factor: 8.807

6.  H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway.

Authors:  A Apolloni; I A Prior; M Lindsay; R G Parton; J F Hancock
Journal:  Mol Cell Biol       Date:  2000-04       Impact factor: 4.272

7.  A unique platform for H-Ras signaling involving clathrin-independent endocytosis.

Authors:  Natalie Porat-Shliom; Yoel Kloog; Julie G Donaldson
Journal:  Mol Biol Cell       Date:  2007-12-19       Impact factor: 4.138

8.  RKTG sequesters B-Raf to the Golgi apparatus and inhibits the proliferation and tumorigenicity of human malignant melanoma cells.

Authors:  Fengjuan Fan; Lin Feng; Jing He; Xiao Wang; Xiaomeng Jiang; Yixuan Zhang; Zhenzhen Wang; Yan Chen
Journal:  Carcinogenesis       Date:  2008-05-29       Impact factor: 4.944

9.  A restricted spectrum of NRAS mutations causes Noonan syndrome.

Authors:  Ion C Cirstea; Kerstin Kutsche; Radovan Dvorsky; Lothar Gremer; Claudio Carta; Denise Horn; Amy E Roberts; Francesca Lepri; Torsten Merbitz-Zahradnik; Rainer König; Christian P Kratz; Francesca Pantaleoni; Maria L Dentici; Victoria A Joshi; Raju S Kucherlapati; Laura Mazzanti; Stefan Mundlos; Michael A Patton; Margherita Cirillo Silengo; Cesare Rossi; Giuseppe Zampino; Cristina Digilio; Liborio Stuppia; Eva Seemanova; Len A Pennacchio; Bruce D Gelb; Bruno Dallapiccola; Alfred Wittinghofer; Mohammad R Ahmadian; Marco Tartaglia; Martin Zenker
Journal:  Nat Genet       Date:  2009-12-06       Impact factor: 38.330

10.  A clathrin-dependent pathway leads to KRas signaling on late endosomes en route to lysosomes.

Authors:  Albert Lu; Francesc Tebar; Blanca Alvarez-Moya; Cristina López-Alcalá; Maria Calvo; Carlos Enrich; Neus Agell; Takeshi Nakamura; Michiyuki Matsuda; Oriol Bachs
Journal:  J Cell Biol       Date:  2009-03-16       Impact factor: 10.539
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  98 in total

1.  The Ras G Domain Lacks the Intrinsic Propensity to Form Dimers.

Authors:  Elizaveta A Kovrigina; Azamat R Galiakhmetov; Evgenii L Kovrigin
Journal:  Biophys J       Date:  2015-09-01       Impact factor: 4.033

2.  The small GTPases K-Ras, N-Ras, and H-Ras have distinct biochemical properties determined by allosteric effects.

Authors:  Christian W Johnson; Derion Reid; Jillian A Parker; Shores Salter; Ryan Knihtila; Petr Kuzmic; Carla Mattos
Journal:  J Biol Chem       Date:  2017-06-19       Impact factor: 5.157

3.  Dual Farnesyl and Geranylgeranyl Transferase Inhibitor Thwarts Mutant KRAS-Driven Patient-Derived Pancreatic Tumors.

Authors:  Aslamuzzaman Kazi; Shengyan Xiang; Hua Yang; Liwei Chen; Perry Kennedy; Muhammad Ayaz; Steven Fletcher; Christopher Cummings; Harshani R Lawrence; Francisca Beato; Ya'an Kang; Michael P Kim; Andrea Delitto; Patrick W Underwood; Jason B Fleming; Jose G Trevino; Andrew D Hamilton; Said M Sebti
Journal:  Clin Cancer Res       Date:  2019-06-21       Impact factor: 12.531

Review 4.  Ras and Rap1: A tale of two GTPases.

Authors:  Seema Shah; Ethan J Brock; Kyungmin Ji; Raymond R Mattingly
Journal:  Semin Cancer Biol       Date:  2018-04-03       Impact factor: 15.707

Review 5.  Control of Ras-mediated signaling in Aspergillus fumigatus.

Authors:  Tiffany S Norton; Jarrod R Fortwendel
Journal:  Mycopathologia       Date:  2014-06-22       Impact factor: 2.574

6.  Membrane Curvature and Lipid Composition Synergize To Regulate N-Ras Anchor Recruitment.

Authors:  Jannik B Larsen; Celeste Kennard; Søren L Pedersen; Knud J Jensen; Mark J Uline; Nikos S Hatzakis; Dimitrios Stamou
Journal:  Biophys J       Date:  2017-07-21       Impact factor: 4.033

7.  Visualization of HRas Domains in the Plasma Membrane of Fibroblasts.

Authors:  Anna Pezzarossa; Franziska Zosel; Thomas Schmidt
Journal:  Biophys J       Date:  2015-04-21       Impact factor: 4.033

Review 8.  Recent advances in protein prenyltransferases: substrate identification, regulation, and disease interventions.

Authors:  Elaina A Zverina; Corissa L Lamphear; Elia N Wright; Carol A Fierke
Journal:  Curr Opin Chem Biol       Date:  2012-11-08       Impact factor: 8.822

9.  Ras nanoclusters: a new drug target?

Authors:  Kwang-Jin Cho; John F Hancock
Journal:  Small GTPases       Date:  2013-01-01

10.  Signal integration by lipid-mediated spatial cross talk between Ras nanoclusters.

Authors:  Yong Zhou; Hong Liang; Travis Rodkey; Nicholas Ariotti; Robert G Parton; John F Hancock
Journal:  Mol Cell Biol       Date:  2013-12-23       Impact factor: 4.272
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