Literature DB >> 21922639

Noninvasive imaging of ethanol-induced developmental defects in zebrafish embryos using optical coherence tomography.

K Divakar Rao1, Piyush Upadhyaya, Mrinalini Sharma, P K Gupta.   

Abstract

In this article, we report the use of optical coherence tomography for noninvasive cross-sectional real-time imaging of ethanol-induced developmental defects in zebrafish embryos larvae. For ethanol concentration of over 300 mM, developmental defects of eye (shrinkage and retinal abnormalities), malformation of the notochord and ataxia arising due to the toxic effects of ethanol were observed in OCT images from 3 days post fertilization onwards. The results suggest that OCT could be a valuable tool for noninvasive assessment of birth defects in small animal systems.
© 2011 Wiley-Liss, Inc.

Entities:  

Keywords:  developmental defects; embryo/fetal physiology; ethanol toxicity; optical coherence tomography

Mesh：

Substances：

Year:  2011        PMID： 21922639     DOI： 10.1002/bdrb.20332

Source DB:  PubMed          Journal:  Birth Defects Res B Dev Reprod Toxicol        ISSN： 1542-9733


  8 in total

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