Jing Li1, Ren Zhao. 1. Department of General Surgery, Ruijin Hospital, Shanghai Jiaotong University, No.197 Ruijin Er Road, Shanghai, 200025, China.
Abstract
INTRODUCTION: L: -plastin, an actin-binding protein, is upregulated in many tumours, including colorectal carcinoma. This study evaluated the expression of L: -plastin in plasma and colorectal tumour tissue and analysed the correlation between clinicopathological staging and prognosis. MATERIALS AND METHODS: Enzyme-linked immunosorbent assay was used to detect L: -plastin in the plasma of 120 colorectal carcinoma patients and 40 control subjects. Immunohistochemistry analyses were also used. RESULTS: The rate of positive L: -plastin expression was significantly higher in colorectal carcinoma patients than in control subjects, and was significantly higher in tumour tissues than in the tissues surrounding the tumour. L: -Plastin expression also is correlated with tumour grade and size, and lymph node metastasis. However, there was no correlation with the extent of tumour invasion or distant metastasis. CONCLUSION: L: -Plastin may be a useful marker for screening colorectal carcinoma and determining the prognosis of patients with colorectal carcinoma, and for genetic therapy and targeted therapy of colorectal carcinoma.
INTRODUCTION:L: -plastin, an actin-binding protein, is upregulated in many tumours, including colorectal carcinoma. This study evaluated the expression of L: -plastin in plasma and colorectal tumour tissue and analysed the correlation between clinicopathological staging and prognosis. MATERIALS AND METHODS: Enzyme-linked immunosorbent assay was used to detect L: -plastin in the plasma of 120 colorectal carcinomapatients and 40 control subjects. Immunohistochemistry analyses were also used. RESULTS: The rate of positive L: -plastin expression was significantly higher in colorectal carcinomapatients than in control subjects, and was significantly higher in tumour tissues than in the tissues surrounding the tumour. L: -Plastin expression also is correlated with tumour grade and size, and lymph node metastasis. However, there was no correlation with the extent of tumour invasion or distant metastasis. CONCLUSION:L: -Plastin may be a useful marker for screening colorectal carcinoma and determining the prognosis of patients with colorectal carcinoma, and for genetic therapy and targeted therapy of colorectal carcinoma.
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