Literature DB >> 21922078

An Image Driven Systems Biology Approach for Neurodegenerative Disease Studies in the TSC-mTOR Pathway.

Dominik Beck1, Xiaobo Zhou, Tuan Pham, Bernardo Sabatini, Stephen T C Wong.   

Abstract

In this brief paper we present an overview of the TSC-mTOR pathway and its importance in neurodegenerative disease (ND). We illustrate the influence of ND on dendritic spine morphology. Then we discuss some details of functional gene networks (FGN) and use this information to propose an image driven systems biology approach for the construction of a FGN for ND. We conclude on its importance and the prospective outcome of our study.

Entities:  

Year:  2009        PMID： 21922078      PMCID： PMC3171509          DOI： 10.1109/LISSA.2009.4906703

Source DB:  PubMed          Journal:  IEEE NIH Life Sci Syst Appl Workshop


  36 in total

1.  Molecular mechanisms contributing to dendritic spine alterations in the prefrontal cortex of subjects with schizophrenia.

Authors:  J J Hill; T Hashimoto; D A Lewis
Journal:  Mol Psychiatry       Date:  2006-06       Impact factor: 15.992

Review 2.  Role of mTOR in physiology and pathology of the nervous system.

Authors:  Lukasz Swiech; Malgorzata Perycz; Anna Malik; Jacek Jaworski
Journal:  Biochim Biophys Acta       Date:  2007-08-24

Review 3.  Balancing structure and function at hippocampal dendritic spines.

Authors:  Jennifer N Bourne; Kristen M Harris
Journal:  Annu Rev Neurosci       Date:  2008       Impact factor: 12.449

4.  A structural basis for enhancement of long-term associative memory in single dendritic spines regulated by PKC.

Authors:  Jarin Hongpaisan; Daniel L Alkon
Journal:  Proc Natl Acad Sci U S A       Date:  2007-12-04       Impact factor: 11.205

5.  Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast.

Authors:  J Heitman; N R Movva; M N Hall
Journal:  Science       Date:  1991-08-23       Impact factor: 47.728

6.  A probabilistic functional network of yeast genes.

Authors:  Insuk Lee; Shailesh V Date; Alex T Adai; Edward M Marcotte
Journal:  Science       Date:  2004-11-26       Impact factor: 47.728

7.  Rapid loss of dendritic spines after stress involves derangement of spine dynamics by corticotropin-releasing hormone.

Authors:  Yuncai Chen; Céline M Dubé; Courtney J Rice; Tallie Z Baram
Journal:  J Neurosci       Date:  2008-03-12       Impact factor: 6.167

8.  Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: effects on mTORC1 and Akt signaling lead to improved survival and function.

Authors:  Lynsey Meikle; Kristen Pollizzi; Anna Egnor; Ioannis Kramvis; Heidi Lane; Mustafa Sahin; David J Kwiatkowski
Journal:  J Neurosci       Date:  2008-05-21       Impact factor: 6.167

Review 9.  The TSC1-TSC2 complex: a molecular switchboard controlling cell growth.

Authors:  Jingxiang Huang; Brendan D Manning
Journal:  Biochem J       Date:  2008-06-01       Impact factor: 3.857

10.  A computational analysis of protein-protein interaction networks in neurodegenerative diseases.

Authors:  Joaquín Goñi; Francisco J Esteban; Nieves Vélez de Mendizábal; Jorge Sepulcre; Sergio Ardanza-Trevijano; Ion Agirrezabal; Pablo Villoslada
Journal:  BMC Syst Biol       Date:  2008-06-20
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