Literature DB >> 21918113

Neisseria gonorrhoeae NspA induces specific bactericidal and opsonic antibodies in mice.

Guocai Li1, Hongmei Jiao, Guihua Jiang, Jing Wang, Litian Zhu, Rushan Xie, Hua Yan, Hongju Chen, Mingchun Ji.   

Abstract

Neisseria gonorrhoeae surface protein A (NspA) is a highly conserved gonococcal antigen. To explore the potential of NspA in vaccine development against gonorrhea, BALB/c mice were immunized with pcNspA containing the NspA gene from N. gonorrhoeae strain WHO-A via intramuscular (i.m.) injection, intranasal (i.n.) immunization, or intravaginal (i.vag.) immunization. Following the last DNA immunization, mice were boosted with recombinant NspA (rNspA). Enzyme-linked immunosorbent assays (ELISAs) indicated that all immunized mice generated measurable NspA-specific IgG and IgA in serum and secretory IgA (sIgA) in vaginal wash fluids. The antisera had bactericidal and opsonic activities. These data demonstrated that NspA induced antibodies with antigonococcal activity.

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Year:  2011        PMID： 21918113      PMCID： PMC3209019          DOI： 10.1128/CVI.05245-11

Source DB:  PubMed          Journal:  Clin Vaccine Immunol        ISSN： 1556-679X


  45 in total

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Journal:  J Immunol       Date:  2001-03-01       Impact factor: 5.422

5.  Differences in surface expression of NspA among Neisseria meningitidis group B strains.

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Journal:  Infect Immun       Date:  1999-11       Impact factor: 3.441

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9.  Membranous cells in nasal-associated lymphoid tissue: a portal of entry for the respiratory mucosal pathogen group A streptococcus.

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6.  Antibodies with higher bactericidal activity induced by a Neisseria gonorrhoeae Rmp deletion mutant strain.

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Review 7.  Is gonococcal disease preventable? The importance of understanding immunity and pathogenesis in vaccine development.

Authors:  Jennifer L Edwards; Michael P Jennings; Michael A Apicella; Kate L Seib
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8.  Oral Immunization of Rabbits with S. enterica Typhimurium Expressing Neisseria gonorrhoeae Filamentous Phage Φ6 Induces Bactericidal Antibodies Against N. gonorrhoeae.

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9.  Structure of the Recombinant Neisseria gonorrhoeae Adhesin Complex Protein (rNg-ACP) and Generation of Murine Antibodies with Bactericidal Activity against Gonococci.

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10.  Chimeric hepatitis B virus core particles displaying Neisserial surface protein A confer protection against virulent Neisseria meningitidis serogroup B in BALB/c mice.

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  10 in total

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