BACKGROUND: After identifying a student with triple-reassortant swine influenza virus (SIV) infection and pig exposure at a livestock event, we investigated whether others were infected and if human-to-human transmission occurred. METHODS: We conducted a cohort study and serosurvey among persons exposed to (1) event pigs, (2) other pigs, (3) the index case, and (4) persons without pig or index case exposure. Confirmed cases had respiratory specimens positive for SIV within 2 weeks of the index case's illness. Probable and suspected cases had illness and (1) exposure to any pig or (2) contact with a confirmed case preceding illness. Probable cases were seropositive. Suspected cases did not give serum samples. RESULTS: Of 99 event pig-exposed students, 72 (73%) participated in the investigation, and 42 (42%) provided serum samples, of whom 17 (40%) were seropositive and 5 (12%) met case criteria. Of 9 students exposed to other pigs, 2 (22%) were seropositive. Of 8 index case-exposed persons and 10 without exposures, none were seropositive. Pig-exposed persons were more likely to be seropositive than persons without pig exposure (37% vs 0%, P < .01). CONCLUSIONS: We identified an outbreak of human SIV infection likely associated with a livestock event; there was no evidence of human-to-human transmission.
BACKGROUND: After identifying a student with triple-reassortant swine influenza virus (SIV) infection and pig exposure at a livestock event, we investigated whether others were infected and if human-to-human transmission occurred. METHODS: We conducted a cohort study and serosurvey among persons exposed to (1) event pigs, (2) other pigs, (3) the index case, and (4) persons without pig or index case exposure. Confirmed cases had respiratory specimens positive for SIV within 2 weeks of the index case's illness. Probable and suspected cases had illness and (1) exposure to any pig or (2) contact with a confirmed case preceding illness. Probable cases were seropositive. Suspected cases did not give serum samples. RESULTS: Of 99 event pig-exposed students, 72 (73%) participated in the investigation, and 42 (42%) provided serum samples, of whom 17 (40%) were seropositive and 5 (12%) met case criteria. Of 9 students exposed to other pigs, 2 (22%) were seropositive. Of 8 index case-exposed persons and 10 without exposures, none were seropositive. Pig-exposed persons were more likely to be seropositive than persons without pig exposure (37% vs 0%, P < .01). CONCLUSIONS: We identified an outbreak of humanSIV infection likely associated with a livestock event; there was no evidence of human-to-human transmission.
Authors: Adena Greenbaum; Celia Quinn; Jennifer Bailer; Su Su; Fiona Havers; Lizette O Durand; Victoria Jiang; Shannon Page; Jeremy Budd; Michael Shaw; Matthew Biggerstaff; Sietske de Fijter; Kathleen Smith; Carrie Reed; Scott Epperson; Lynnette Brammer; Dave Feltz; Kevin Sohner; Jared Ford; Seema Jain; Paul Gargiullo; Edward Weiss; Pat Burg; Mary DiOrio; Brian Fowler; Lyn Finelli; Michael A Jhung Journal: J Infect Dis Date: 2015-05-05 Impact factor: 5.226
Authors: Tatiana Baranovich; Justin Bahl; Bindumadhav M Marathe; Marie Culhane; Evelyn Stigger-Rosser; Daniel Darnell; Bryan S Kaplan; James F Lowe; Richard J Webby; Elena A Govorkova Journal: Antiviral Res Date: 2015-02-19 Impact factor: 5.970
Authors: Mary J Choi; Montserrat Torremorell; Jeff B Bender; Kirk Smith; David Boxrud; Jon R Ertl; My Yang; Kamol Suwannakarn; Duachi Her; Jennifer Nguyen; Timothy M Uyeki; Min Levine; Stephen Lindstrom; Jacqueline M Katz; Michael Jhung; Sara Vetter; Karen K Wong; Srinand Sreevatsan; Ruth Lynfield Journal: Clin Infect Dis Date: 2015-07-29 Impact factor: 9.079
Authors: Karen K Wong; Adena Greenbaum; Maria E Moll; James Lando; Erin L Moore; Rahul Ganatra; Matthew Biggerstaff; Eugene Lam; Erica E Smith; Aaron D Storms; Jeffrey R Miller; Virginia Dato; Kumar Nalluswami; Atmaram Nambiar; Sharon A Silvestri; James R Lute; Stephen Ostroff; Kathy Hancock; Alicia Branch; Susan C Trock; Alexander Klimov; Bo Shu; Lynnette Brammer; Scott Epperson; Lyn Finelli; Michael A Jhung Journal: Emerg Infect Dis Date: 2012-12 Impact factor: 6.883
Authors: Kirsty R Short; Mathilde Richard; Josanne H Verhagen; Debby van Riel; Eefje J A Schrauwen; Judith M A van den Brand; Benjamin Mänz; Rogier Bodewes; Sander Herfst Journal: One Health Date: 2015-12-01