Literature DB >> 21917454

Design, synthesis and SAR of indazole and benzoisoxazole containing 4-azetidinyl-1-aryl-cyclohexanes as CCR2 antagonists.

Xuqing Zhang1, Heather Hufnagel, Cuifen Hou, Evan Opas, Sandra McKenney, Carl Crysler, John O'Neill, Dana Johnson, Zhihua Sui.   

Abstract

A novel series of 4-azetidinyl-1-aryl-cyclohexanes containing indazole or benzoisoxazole moiety have been identified as potent CCR2 antagonists with high selectivity versus hERG.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 21917454     DOI： 10.1016/j.bmcl.2011.08.074

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  1 in total

1.  Discovery of a 4-Azetidinyl-1-thiazoyl-cyclohexane CCR2 Antagonist as a Development Candidate.

Authors:  Xuqing Zhang; Cuifen Hou; Heather Hufnagel; Monica Singer; Evan Opas; Sandra McKenney; Dana Johnson; Zhihua Sui
Journal:  ACS Med Chem Lett       Date:  2012-10-08       Impact factor: 4.345
  1 in total

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