Literature DB >> 21917453

Protective effects of amentoflavone on Lamin A-dependent UVB-induced nuclear aberration in normal human fibroblasts.

Nok-Hyun Park1, Chan-Woo Lee, Ji-Hyun Bae, Yong Joo Na.   

Abstract

Lamin A-dependent nuclear aberration and DNA damage was found in premature aging disease or normally old individuals. In this study, UVB irradiation was used as a cellular senescence inducer, and it was found that Lamin A and phospho-H2AX protein was increased by UVB treatment on normal human fibroblast. Lamin A-dependent morphological nuclear defect was observed in UVB treated fibroblast. Amentoflavone, a well known biflavonoid, inhibited the increase of Lamin A or phospho-H2AX protein in dose dependent manner which was induced by UVB irradiation, and also protected nuclear aberration dramatically. These results indicated that amentoflavone is an anti-aging candidate for UVB related skin aging process. Crown
Copyright © 2011. Published by Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 21917453     DOI： 10.1016/j.bmcl.2011.08.067

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  10 in total

1.  Amentoflavone enhances osteogenesis of human mesenchymal stem cells through JNK and p38 MAPK pathways.

Authors:  Xuan Zha; Zhoumei Xu; Yuyu Liu; Liangliang Xu; Hongxin Huang; Jingjing Zhang; Liao Cui; Chenhui Zhou; Daohua Xu
Journal:  J Nat Med       Date:  2016-04-22       Impact factor: 2.343

2.  Amentoflavone derivatives significantly act towards the main protease (3CLPRO/MPRO) of SARS-CoV-2: in silico admet profiling, molecular docking, molecular dynamics simulation, network pharmacology.

Authors:  Dipta Dey; Rajib Hossain; Partha Biswas; Priyanka Paul; Md Aminul Islam; Tanzila Ismail Ema; Bibhuti Kumar Gain; Mohammad Mehedi Hasan; Shabana Bibi; Muhammad Torequl Islam; Md Ataur Rahman; Bonglee Kim
Journal:  Mol Divers       Date:  2022-05-31       Impact factor: 3.364

3.  Exploring Phytochemicals of Traditional Medicinal Plants Exhibiting Inhibitory Activity Against Main Protease, Spike Glycoprotein, RNA-dependent RNA Polymerase and Non-Structural Proteins of SARS-CoV-2 Through Virtual Screening.

Authors:  Saranya Nallusamy; Jayakanthan Mannu; Caroline Ravikumar; Kandavelmani Angamuthu; Bharathi Nathan; Kumaravadivel Nachimuthu; Gnanam Ramasamy; Raveendran Muthurajan; Mohankumar Subbarayalu; Kumar Neelakandan
Journal:  Front Pharmacol       Date:  2021-07-08       Impact factor: 5.810

4.  Amentoflavone protects against high fat-induced metabolic dysfunction: Possible role of the regulation of adipogenic differentiation.

Authors:  Guangyong Chen; Yangdong Han; Wang He; Feng Liang
Journal:  Int J Mol Med       Date:  2016-10-14       Impact factor: 4.101

Review 5.  A Review on the Phytochemistry, Pharmacology, and Pharmacokinetics of Amentoflavone, a Naturally-Occurring Biflavonoid.

Authors:  Sheng Yu; Hui Yan; Li Zhang; Mingqiu Shan; Peidong Chen; Anwei Ding; Sam Fong Yau Li
Journal:  Molecules       Date:  2017-02-16       Impact factor: 4.411

6.  Proliposomes for oral delivery of total biflavonoids extract from Selaginella doederleinii: formulation development, optimization, and in vitro-in vivo characterization.

Authors:  Bing Chen; Xuewen Wang; Dan Lin; Dafen Xu; Shaoguang Li; Jianyong Huang; Shaohuang Weng; Zhen Lin; Yanjie Zheng; Hong Yao; Xinhua Lin
Journal:  Int J Nanomedicine       Date:  2019-08-20

Review 7.  Insights Into Amentoflavone: A Natural Multifunctional Biflavonoid.

Authors:  Xifeng Xiong; Nan Tang; Xudong Lai; Jinli Zhang; Weilun Wen; Xiaojian Li; Aiguo Li; Yanhua Wu; Zhihe Liu
Journal:  Front Pharmacol       Date:  2021-12-22       Impact factor: 5.810

8.  Hierarchical network analysis of co-occurring bioentities in literature.

Authors:  Heejung Yang; Namgil Lee; Beomjun Park; Jinyoung Park; Jiho Lee; Hyeon Seok Jang; Hojin Yoo
Journal:  Sci Rep       Date:  2022-05-12       Impact factor: 4.996

Review 9.  The cell biology of aging.

Authors:  Race DiLoreto; Coleen T Murphy
Journal:  Mol Biol Cell       Date:  2015-12-15       Impact factor: 4.138

10.  Amentoflavone protects hippocampal neurons: anti-inflammatory, antioxidative, and antiapoptotic effects.

Authors:  Zhen Zhang; Tao Sun; Jian-Guo Niu; Zhen-Quan He; Yang Liu; Feng Wang
Journal:  Neural Regen Res       Date:  2015-07       Impact factor: 5.135
  10 in total

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