BACKGROUND: Treatment options for patients with metastatic uterine leiomyosarcoma are limited. Over the last few years, trabectedin has emerged as an effective agent for patients with advanced soft tissue sarcomas resistant to anthracyclines and ifosfamide. The aim of this retrospective analysis was to look at the efficacy of trabectedin in the subgroup of uterine leiomyosarcoma. PATIENTS AND METHODS: A retrospective analysis was carried out on patients with uterine leiomyosarcoma treated with trabectedin at two reference sarcoma centers between 2000 and 2010. Radiological response, progression-free and overall survival, as well as serious and unexpected adverse events, were assessed. RESULTS: Sixty-six patients with metastatic uterine leiomyosarcoma were identified. The median number of previous chemotherapy regimens was 3 (range 1-5). Eleven patients (16%) achieved a partial response and 23 (35%) had a stable disease. The progression-free survival of the entire cohort was 3.3 months (CI 95% 2-5), and the progression-free rate at 3 and 6 months was 53% and 33%, respectively. CONCLUSIONS: Trabectedin is a therapeutic option in the palliative approach to the metastatic uterine leiomyosarcoma patient.
BACKGROUND: Treatment options for patients with metastatic uterine leiomyosarcoma are limited. Over the last few years, trabectedin has emerged as an effective agent for patients with advanced soft tissue sarcomas resistant to anthracyclines and ifosfamide. The aim of this retrospective analysis was to look at the efficacy of trabectedin in the subgroup of uterine leiomyosarcoma. PATIENTS AND METHODS: A retrospective analysis was carried out on patients with uterine leiomyosarcoma treated with trabectedin at two reference sarcoma centers between 2000 and 2010. Radiological response, progression-free and overall survival, as well as serious and unexpected adverse events, were assessed. RESULTS: Sixty-six patients with metastatic uterine leiomyosarcoma were identified. The median number of previous chemotherapy regimens was 3 (range 1-5). Eleven patients (16%) achieved a partial response and 23 (35%) had a stable disease. The progression-free survival of the entire cohort was 3.3 months (CI 95% 2-5), and the progression-free rate at 3 and 6 months was 53% and 33%, respectively. CONCLUSIONS: Trabectedin is a therapeutic option in the palliative approach to the metastatic uterine leiomyosarcomapatient.
Authors: Martee L Hensley; Brigitte A Barrette; Klaus Baumann; David Gaffney; Anne L Hamilton; Jae-Weon Kim; Johanna U Maenpaa; Patricia Pautier; Nadeem Ahmad Siddiqui; Anneke M Westermann; Isabelle Ray-Coquard Journal: Int J Gynecol Cancer Date: 2014-11 Impact factor: 3.437
Authors: Julia A Elvin; Laurie M Gay; Rita Ort; Joseph Shuluk; Jennifer Long; Lauren Shelley; Ronald Lee; Zachary R Chalmers; Garrett M Frampton; Siraj M Ali; Alexa B Schrock; Vincent A Miller; Philip J Stephens; Jeffrey S Ross; Richard Frank Journal: Oncologist Date: 2017-03-10
Authors: H J Mackay; R J Buckanovich; H Hirte; R Correa; P Hoskins; J Biagi; L P Martin; G F Fleming; R Morgan; L Wang; R Polintan; A M Oza Journal: Gynecol Oncol Date: 2011-12-02 Impact factor: 5.482
Authors: Martee L Hensley; Shreyaskumar R Patel; Margaret von Mehren; Kristen Ganjoo; Robin L Jones; Arthur Staddon; Daniel Rushing; Mohammed Milhem; Bradley Monk; George Wang; Sharon McCarthy; Roland E Knoblauch; Trilok V Parekh; Robert G Maki; George D Demetri Journal: Gynecol Oncol Date: 2017-06-24 Impact factor: 5.482