Literature DB >> 21916427

Regulators of G protein signaling (RGS) proteins as drug targets: modulating G-protein-coupled receptor (GPCR) signal transduction.

David L Roman1, John R Traynor.   

Abstract

Entities:  

Mesh：

Substances：

Year:  2011        PMID： 21916427      PMCID： PMC3208131          DOI： 10.1021/jm101572n

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


× No keyword cloud information.
  69 in total

1.  Most central nervous system D2 dopamine receptors are coupled to their effectors by Go.

Authors:  M Jiang; K Spicher; G Boulay; Y Wang; L Birnbaumer
Journal:  Proc Natl Acad Sci U S A       Date:  2001-03-06       Impact factor: 11.205

2.  Receptor-selective effects of endogenous RGS3 and RGS5 to regulate mitogen-activated protein kinase activation in rat vascular smooth muscle cells.

Authors:  Qin Wang; Min Liu; Bashar Mullah; David P Siderovski; Richard R Neubig
Journal:  J Biol Chem       Date:  2002-05-02       Impact factor: 5.157

Review 3.  The 5-HT1A receptor in schizophrenia: a promising target for novel atypical neuroleptics?

Authors:  R A Bantick; J F Deakin; P M Grasby
Journal:  J Psychopharmacol       Date:  2001-03       Impact factor: 4.153

Review 4.  Regulator of G protein signaling proteins: novel multifunctional drug targets.

Authors:  H Zhong; R R Neubig
Journal:  J Pharmacol Exp Ther       Date:  2001-06       Impact factor: 4.030

5.  Mechanism of action and structural requirements of constrained peptide inhibitors of RGS proteins.

Authors:  Rebecca A Roof; Yafei Jin; David L Roman; Roger K Sunahara; Masaru Ishii; Henry I Mosberg; Richard R Neubig
Journal:  Chem Biol Drug Des       Date:  2006-04       Impact factor: 2.817

6.  Pleiotropic phenotype of a genomic knock-in of an RGS-insensitive G184S Gnai2 allele.

Authors:  Xinyan Huang; Ying Fu; Raelene A Charbeneau; Thomas L Saunders; Douglas K Taylor; Kurt D Hankenson; Mark W Russell; Louis G D'Alecy; Richard R Neubig
Journal:  Mol Cell Biol       Date:  2006-09       Impact factor: 4.272

7.  Endogenous RGS proteins and Galpha subtypes differentially control muscarinic and adenosine-mediated chronotropic effects.

Authors:  Ying Fu; Xinyan Huang; Huailing Zhong; Richard M Mortensen; Louis G D'Alecy; Richard R Neubig
Journal:  Circ Res       Date:  2006-02-02       Impact factor: 17.367

8.  Regional alterations in RGS4 protein in schizophrenia.

Authors:  Holly A Erdely; Carol A Tamminga; Rosalinda C Roberts; Michael W Vogel
Journal:  Synapse       Date:  2006-06-15       Impact factor: 2.562

9.  Elevated levels of DeltaFosB and RGS9 in striatum in Parkinson's disease.

Authors:  P K Tekumalla; F Calon; Z Rahman; S Birdi; A H Rajput; O Hornykiewicz; T Di Paolo; P J Bédard; E J Nestler
Journal:  Biol Psychiatry       Date:  2001-11-15       Impact factor: 13.382

10.  Chemical genetics reveals an RGS/G-protein role in the action of a compound.

Authors:  Kevin Fitzgerald; Svetlana Tertyshnikova; Lisa Moore; Lynn Bjerke; Ben Burley; Jian Cao; Pamela Carroll; Robert Choy; Steve Doberstein; Yves Dubaquie; Yvonne Franke; Jenny Kopczynski; Hendrik Korswagen; Stanley R Krystek; Nicholas J Lodge; Ronald Plasterk; John Starrett; Terry Stouch; George Thalody; Honey Wayne; Alexander van der Linden; Yongmei Zhang; Stephen G Walker; Mark Cockett; Judi Wardwell-Swanson; Petra Ross-Macdonald; Rachel M Kindt
Journal:  PLoS Genet       Date:  2006-04-21       Impact factor: 5.917
View more
  25 in total

Review 1.  Toward Small-Molecule Inhibition of Protein-Protein Interactions: General Aspects and Recent Progress in Targeting Costimulatory and Coinhibitory (Immune Checkpoint) Interactions.

Authors:  Damir Bojadzic; Peter Buchwald
Journal:  Curr Top Med Chem       Date:  2018       Impact factor: 3.295

Review 2.  Current approaches for the discovery of drugs that deter substance and drug abuse.

Authors:  Adam Yasgar; Anton Simeonov
Journal:  Expert Opin Drug Discov       Date:  2014-09-24       Impact factor: 6.098

Review 3.  Regulating the regulators: Epigenetic, transcriptional, and post-translational regulation of RGS proteins.

Authors:  Mohammed Alqinyah; Shelley B Hooks
Journal:  Cell Signal       Date:  2017-10-16       Impact factor: 4.315

4.  Interplay of cysteine exposure and global protein dynamics in small-molecule recognition by a regulator of G-protein signaling protein.

Authors:  Mohammadjavad Mohammadi; Hossein Mohammadiarani; Vincent S Shaw; Richard R Neubig; Harish Vashisth
Journal:  Proteins       Date:  2018-12-26

5.  Differential effects of the Gβ5-RGS7 complex on muscarinic M3 receptor-induced Ca2+ influx and release.

Authors:  Darla Karpinsky-Semper; Claude-Henry Volmar; Shaun P Brothers; Vladlen Z Slepak
Journal:  Mol Pharmacol       Date:  2014-02-28       Impact factor: 4.436

6.  Conformational dynamics of a regulator of G-protein signaling protein reveals a mechanism of allosteric inhibition by a small molecule.

Authors:  Harish Vashisth; Andrew J Storaska; Richard R Neubig; Charles L Brooks
Journal:  ACS Chem Biol       Date:  2013-10-24       Impact factor: 5.100

Review 7.  Roles for Regulator of G Protein Signaling Proteins in Synaptic Signaling and Plasticity.

Authors:  Kyle J Gerber; Katherine E Squires; John R Hepler
Journal:  Mol Pharmacol       Date:  2015-12-11       Impact factor: 4.436

8.  RGS17: an emerging therapeutic target for lung and prostate cancers.

Authors:  Christopher R Bodle; Duncan I Mackie; David L Roman
Journal:  Future Med Chem       Date:  2013-06       Impact factor: 3.808

9.  Evaluation of the Selectivity and Cysteine Dependence of Inhibitors across the Regulator of G Protein-Signaling Family.

Authors:  Michael P Hayes; Christopher R Bodle; David L Roman
Journal:  Mol Pharmacol       Date:  2017-10-19       Impact factor: 4.436

10.  Characterization of binding kinetics of A2AR to Gαs protein by surface plasmon resonance.

Authors:  Kirsten S Koretz; Claire E McGraw; Steven Stradley; Ahmed Elbaradei; Noah Malmstadt; Anne S Robinson
Journal:  Biophys J       Date:  2021-03-04       Impact factor: 4.033
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.