Literature DB >> 21915395

Exploring isonitrile-based click chemistry for ligation with biomolecules.

Henning Stöckmann1, André A Neves, Shaun Stairs, Kevin M Brindle, Finian J Leeper.   

Abstract

We show here that isonitriles can perform click reactions with tetrazines in aqueous media, making them promising candidates for ligation reactions in chemical biology and polymer chemistry. This is the first time that a [4+1] cycloaddition has been used as a biocompatible ligation reaction.

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Year:  2011        PMID： 21915395     DOI： 10.1039/c1ob06424j

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


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