OBJECTIVE: The work aimed to study the potential correlation between the high-level benzene exposure and its urinary metabolites S-phenylmercapturic acid (SPMA) and trans, trans-muconic acid (t,t-MA) in Chinese shoe-making workers. METHODS: Individual benzene-exposed levels were determined by gas chromatography analysis, urinary t,t-MA, and urinary SPMA were determined by high performance liquid chromatography-an ultraviolet detector and liquid chromatography/electrospray tandem mass spectrometry method, respectively. RESULTS: The concentration of benzene ranged from 2.57 to 146.11 mg/m³. And the correlation between benzene and t,t-MA was significantly higher than that of SPMA at the postshift, for example, the correlation coefficient was 0.905 and 0.537 for t,t-MA and SPMA, respectively. Moreover, The relative internal exposure index of t,t-MA (0.28 mg/g Cr: mg/m³) was more similar to the data supplied by American Conference of Governmental Industrial Hygienists compared to the index of SPMA (0.025 mg/g Cr:mg/m³). CONCLUSIONS: t,t-MA appeared to be a more specific biomarker than SPMA at high-level benzene exposure.
OBJECTIVE: The work aimed to study the potential correlation between the high-level benzene exposure and its urinary metabolites S-phenylmercapturic acid (SPMA) and trans, trans-muconic acid (t,t-MA) in Chinese shoe-making workers. METHODS: Individual benzene-exposed levels were determined by gas chromatography analysis, urinary t,t-MA, and urinary SPMA were determined by high performance liquid chromatography-an ultraviolet detector and liquid chromatography/electrospray tandem mass spectrometry method, respectively. RESULTS: The concentration of benzene ranged from 2.57 to 146.11 mg/m³. And the correlation between benzene and t,t-MA was significantly higher than that of SPMA at the postshift, for example, the correlation coefficient was 0.905 and 0.537 for t,t-MA and SPMA, respectively. Moreover, The relative internal exposure index of t,t-MA (0.28 mg/g Cr: mg/m³) was more similar to the data supplied by American Conference of Governmental Industrial Hygienists compared to the index of SPMA (0.025 mg/g Cr:mg/m³). CONCLUSIONS: t,t-MA appeared to be a more specific biomarker than SPMA at high-level benzene exposure.
Authors: Ning Qin; Yuanyuan Zhu; Yan Zhong; Jing Tian; Jihua Li; Laiguo Chen; Ruifang Fan; Fusheng Wei Journal: Int J Environ Res Public Health Date: 2022-01-13 Impact factor: 3.390