BACKGROUND: Dyslipidemia, an important risk factor for cardiovascular disease, may be associated with atrial fibrillation (AF). Cross-sectional studies that have examined this association, however, have produced controversial results, and few longitudinal studies have been conducted. METHODS AND RESULTS: Using annual health examinations in Japan, the association between lipid profile and the risk of new-onset AF was investigated in the general population. A total of 28,449 individuals who did not have AF at baseline were included in the study. During a follow-up of 4.5±2.7 years, 265 individuals (0.9%) developed AF. In multivariate models, low high-density lipoprotein (HDL) cholesterol was associated with the development of AF in women (hazard ratio [HR], 2.86; 95% confidence interval [CI]: 1.49-5.50) but not in men (HR, 1.35; 95%CI: 0.77-2.38). Women had a 28% higher risk of AF with each 10% decrease in HDL cholesterol. Neither triglycerides nor lipid ratios were associated with AF. After excluding individuals with risk factors for AF, including those who were taking anti-hypertensive drugs, had diabetes, and structural heart disease, the association between low HDL cholesterol and AF remained significant in women. CONCLUSIONS: Low HDL cholesterol was associated with an increased risk of new-onset AF in women, but not in men.
BACKGROUND:Dyslipidemia, an important risk factor for cardiovascular disease, may be associated with atrial fibrillation (AF). Cross-sectional studies that have examined this association, however, have produced controversial results, and few longitudinal studies have been conducted. METHODS AND RESULTS: Using annual health examinations in Japan, the association between lipid profile and the risk of new-onset AF was investigated in the general population. A total of 28,449 individuals who did not have AF at baseline were included in the study. During a follow-up of 4.5±2.7 years, 265 individuals (0.9%) developed AF. In multivariate models, low high-density lipoprotein (HDL) cholesterol was associated with the development of AF in women (hazard ratio [HR], 2.86; 95% confidence interval [CI]: 1.49-5.50) but not in men (HR, 1.35; 95%CI: 0.77-2.38). Women had a 28% higher risk of AF with each 10% decrease in HDL cholesterol. Neither triglycerides nor lipid ratios were associated with AF. After excluding individuals with risk factors for AF, including those who were taking anti-hypertensive drugs, had diabetes, and structural heart disease, the association between low HDL cholesterol and AF remained significant in women. CONCLUSIONS: Low HDL cholesterol was associated with an increased risk of new-onset AF in women, but not in men.
Authors: Samia Mora; Akintunde O Akinkuolie; Roopinder K Sandhu; David Conen; Christine M Albert Journal: Circ Arrhythm Electrophysiol Date: 2014-05-25
Authors: Sanghamitra Mohanty; Luigi Di Biase; Prasant Mohanty; Pasquale Santangeli; Bai Rong; Trivedy Chintan; David Burkhardt; Joseph G Gallinghouse; Rodney Horton; Javier E Sanchez; Shane Bailey; Jason Zagrodzky; Andrea Natale Journal: J Atr Fibrillation Date: 2013-02-12
Authors: Faye L Lopez; Sunil K Agarwal; Richard F Maclehose; Elsayed Z Soliman; A Richey Sharrett; Rachel R Huxley; Suma Konety; Christie M Ballantyne; Alvaro Alonso Journal: Circ Arrhythm Electrophysiol Date: 2012-01-06