| Literature DB >> 21914894 |
Yuanyuan Zhang1, Chen Chen, Jie Liu, Haijun Deng, Aizhen Pan, Lishui Zhang, Xiuqin Zhao, Mingxiang Huang, Bing Lu, Haiyan Dong, Pengcheng Du, Weijun Chen, KangLin Wan.
Abstract
Mycobacterium tuberculosis is one of most prevalent pathogens in the world. Drug-resistant strains of this pathogen caused by the excessive use of antibiotics have long posed serious threats to public health worldwide. A broader picture of drug resistance mechanisms at the genomic level can be obtained only with large-scale comparative genomic methodology. Two closely related Beijing family isolates, one resistant to four first-line drugs (CCDC5180) and one sensitive to them (CCDC5079), were completely sequenced. These sequences will serve as valuable references for further drug resistance site identification studies and could be of great importance for developing drugs targeting these sites.Entities:
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Year: 2011 PMID： 21914894 PMCID： PMC3187387 DOI： 10.1128/JB.05452-11
Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490