Literature DB >> 21914557

Antibodies to LM1 and LM1-containing ganglioside complexes in Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy.

Motoi Kuwahara1, Seiko Suzuki, Kazuo Takada, Susumu Kusunoki.   

Abstract

LM1 is localized in human peripheral nerve myelin. Antibodies to ganglioside complexes (GSCs) have been reported in Guillain-Barré syndrome (GBS). We investigated IgG antibodies to LM1 and two GSCs (GM1 and LMI, or GD1b and LM1) in the sera of each 40 patients with chronic inflammatory demyelinating polyneuropathy (CIDP) and GBS, using ELISA. We detected anti-LM1 antibody in five with GBS and seven with CIDP; anti-GM1/LM1 antibody in three with GBS and one with CIDP; and anti-GD1b/LM1 antibody in two with CIDP. Antibodies to LM1 and LM1-containing GSCs may be among the targets for autoimmunity in GBS and CIDP.
Copyright © 2011 Elsevier B.V. All rights reserved.

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Year:  2011        PMID： 21914557     DOI： 10.1016/j.jneuroim.2011.08.016

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  11 in total

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Review 5.  Novel pathomechanisms in inflammatory neuropathies.

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6.  Antibodies against peripheral nerve antigens in chronic inflammatory demyelinating polyradiculoneuropathy.

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Journal:  Mediators Inflamm       Date:  2015-09-16       Impact factor: 4.711

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Journal:  JMIR Res Protoc       Date:  2020-04-01

Review 10.  Pathophysiology of Chronic Inflammatory Demyelinating Polyneuropathy: Insights into Classification and Therapeutic Strategy.

Authors:  Haruki Koike; Masahisa Katsuno
Journal:  Neurol Ther       Date:  2020-05-14
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