OBJECTIVE: To evaluate the anti-hyperlipidemic activity of lemongrass oil against in dexamethasone induced hyperlipidemia in rats. METHODS: Administration of dexamethasone was given at 10 mg/kg, sc. to the adult rats for 8 d induces hyperlipidemia characterized by marked increase in serum cholesterol and triglyceride levels along with increase in atherogenic index. RESULTS: Lemongrass oil (100 and 200 mg/kg, po.) treatment has showed significant inhibition against dexamethasone hyperlipidemia by maintaining the serum levels of cholesterol, triglycerides and atherogenic index near to the normal levels and the antihyperlipidemic effect of the lemongross oil was comparable with atorvastatin 10 mg/kg, po. The possible mechanism may be associated with decrease in lecithin cholesterol acetyl transferase (LCAT) activity. CONCLUSIONS: These results suggested that Lemon gross oil possess significant anti-hyperlipidemic activity.
OBJECTIVE: To evaluate the anti-hyperlipidemic activity of lemongrass oil against in dexamethasone induced hyperlipidemia in rats. METHODS: Administration of dexamethasone was given at 10 mg/kg, sc. to the adult rats for 8 d induces hyperlipidemia characterized by marked increase in serum cholesterol and triglyceride levels along with increase in atherogenic index. RESULTS:Lemongrass oil (100 and 200 mg/kg, po.) treatment has showed significant inhibition against dexamethasonehyperlipidemia by maintaining the serum levels of cholesterol, triglycerides and atherogenic index near to the normal levels and the antihyperlipidemic effect of the lemongross oil was comparable with atorvastatin 10 mg/kg, po. The possible mechanism may be associated with decrease in lecithin cholesterol acetyl transferase (LCAT) activity. CONCLUSIONS: These results suggested that Lemon gross oil possess significant anti-hyperlipidemic activity.
Authors: K Vinodraj; I M Nagendra Nayak; J Vikram Rao; Paul Mathai; N Chandralekha; B Nitasha; D Rajesh; T K Chethan Journal: Indian J Pharmacol Date: 2015 Mar-Apr Impact factor: 1.200
Authors: Mona F Mahmoud; Asmaa M Elmaghraby; Noura Ali; Islam Mostafa; Assem M El-Shazly; Mohamed A O Abdelfattah; Mansour Sobeh Journal: Biomed Pharmacother Date: 2022-07-27 Impact factor: 7.419
Authors: Yanliu Lu; Yimei Du; Lin Qin; Di Wu; Wei Wang; Lei Ling; Feifei Ma; Hua Ling; Li Yang; Changhong Wang; Zhengtao Wang; Xumei Zhou; Yuqi He Journal: Evid Based Complement Alternat Med Date: 2018-07-12 Impact factor: 2.629