SirWe read the original article titled “Laparoscopic versus open appendectomy: a comparison of primary outcome measures” by Khalil et al.,[1] with great interest.Randomized controlled trials (RCTs) are principal tools to identify effectiveness of one treatment over another as they bestow least biased estimates of treatment effects.[2] Absence of selection bias and random distribution of confounding factors among different groups make these scientifically rigorous RCTs a preferred choice over case controlled studies.[3] Unfortunately, design of RCTs usually gets less attention than what it deserves. An RCT may involve a number of outcomes. It is of utmost importance to differentiate a primary outcome from a secondary outcome. Primary outcome (end point) is a very critical issue in the design of RCTs. A primary outcome is one which will be used to arrive at a decision on the overall result of the study.[4] Moreover, a primary outcome will also serve the basis to calculate the sample size for a particular RCT. So, a RCT must have only one primary outcome, which should be decided at the outset of the study.Khalil et al.,[1] involved a number of primary outcomes including operative duration, length of hospital stay, and postoperative complications. They have also not mentioned how sample size was calculated. In a review of 42 RCTs comparing open versus laparoscopic appendectomy, Sadr-Azodi et al. concluded that most of these RCTs had low quality.[5] They recommended that adherence to the CONSORT statement[6] and registration of the trial protocol are important tools to improve the quality of trials in the field of surgery.