OBJECTIVE: The relationship between lipid profiles and Alzheimer disease (AD) pathology at the population level is unclear. We searched for evidence of AD-related pathologic risk of abnormal lipid metabolism. METHODS: This study included brain specimens from a series of 147 autopsies performed between 1998 and 2003 of residents in Hisayama town, Japan (76 men and 71 women), who underwent clinical examinations in 1988. Lipid profiles, such as total cholesterol (TC), triglycerides, and high-density lipoprotein cholesterol (HDLC), were measured in 1988. Low-density lipoprotein cholesterol (LDLC) was calculated using the Friedewald formula. Neuritic plaques (NPs) were assessed according to the Consortium to Establish a Registry for Alzheimer's Disease guidelines (CERAD) and neurofibrillary tangles (NFTs) were assessed according to Braak stage. Associations between each lipid profile and AD pathology were examined by analysis of covariance and logistic regression analyses. RESULTS: Adjusted means of TC, LDLC, TC/HDLC, LDLC/HDLC, and non-HDLC (defined as TC-HDLC) were significantly higher in subjects with NPs, even in sparse to moderate stages (CERAD = 1 or 2), compared to subjects without NPs in multivariate models including APOE ε4 carrier and other confounding factors. The subjects in the highest quartiles of these lipid profiles had significantly higher risks of NPs compared to subjects in the lower respective quartiles, which may suggest a threshold effect. Conversely, there was no relationship between any lipid profile and NFTs. CONCLUSION: The results of this study suggest that dyslipidemia increases the risk of plaque-type pathology.
OBJECTIVE: The relationship between lipid profiles and Alzheimer disease (AD) pathology at the population level is unclear. We searched for evidence of AD-related pathologic risk of abnormal lipid metabolism. METHODS: This study included brain specimens from a series of 147 autopsies performed between 1998 and 2003 of residents in Hisayama town, Japan (76 men and 71 women), who underwent clinical examinations in 1988. Lipid profiles, such as total cholesterol (TC), triglycerides, and high-density lipoprotein cholesterol (HDLC), were measured in 1988. Low-density lipoprotein cholesterol (LDLC) was calculated using the Friedewald formula. Neuritic plaques (NPs) were assessed according to the Consortium to Establish a Registry for Alzheimer's Disease guidelines (CERAD) and neurofibrillary tangles (NFTs) were assessed according to Braak stage. Associations between each lipid profile and AD pathology were examined by analysis of covariance and logistic regression analyses. RESULTS: Adjusted means of TC, LDLC, TC/HDLC, LDLC/HDLC, and non-HDLC (defined as TC-HDLC) were significantly higher in subjects with NPs, even in sparse to moderate stages (CERAD = 1 or 2), compared to subjects without NPs in multivariate models including APOE ε4 carrier and other confounding factors. The subjects in the highest quartiles of these lipid profiles had significantly higher risks of NPs compared to subjects in the lower respective quartiles, which may suggest a threshold effect. Conversely, there was no relationship between any lipid profile and NFTs. CONCLUSION: The results of this study suggest that dyslipidemia increases the risk of plaque-type pathology.
Authors: Brianne M Bettcher; M Colin Ard; Bruce R Reed; Andreana Benitez; Amanda Simmons; Eric B Larson; Josh A Sonnen; Thomas J Montine; Ge Li; C Dirk Keene; Paul K Crane; Dan Mungas Journal: J Alzheimers Dis Date: 2017 Impact factor: 4.472
Authors: Li Li; David J Ruau; Chirag J Patel; Susan C Weber; Rong Chen; Nicholas P Tatonetti; Joel T Dudley; Atul J Butte Journal: Sci Transl Med Date: 2014-04-30 Impact factor: 17.956
Authors: Andrew J Schork; Yunpeng Wang; Rahul S Desikan; Wesley K Thompson; Abbas Dehghan; Paul M Ridker; Daniel I Chasman; Linda K McEvoy; Dominic Holland; Chi-Hua Chen; David S Karow; James B Brewer; Christopher P Hess; Julie Williams; Rebecca Sims; Michael C O'Donovan; Seung Hoan Choi; Joshua C Bis; M Arfan Ikram; Vilmundur Gudnason; Anita L DeStefano; Sven J van der Lee; Bruce M Psaty; Cornelia M van Duijn; Lenore Launer; Sudha Seshadri; Margaret A Pericak-Vance; Richard Mayeux; Jonathan L Haines; Lindsay A Farrer; John Hardy; Ingun Dina Ulstein; Dag Aarsland; Tormod Fladby; Linda R White; Sigrid B Sando; Arvid Rongve; Aree Witoelar; Srdjan Djurovic; Bradley T Hyman; Jon Snaedal; Stacy Steinberg; Hreinn Stefansson; Kari Stefansson; Gerard D Schellenberg; Ole A Andreassen; Anders M Dale Journal: Circulation Date: 2015-04-10 Impact factor: 29.690