OBJECTIVE: Previous studies have reported gray matter alterations in patients with migraine, particularly thinning of the cingulate gyrus, and thickening of the somatosensory cortex (SSC) and visual motion processing areas (V3A/MT+). We attempted to replicate these findings in a larger patient population. METHODS: Brain anatomy was collected with 3T MRI. Surface-based morphometry was used to segment each brain volume, reconstruct and inflate the cortical sheet, and estimate gray matter thickness. RESULTS: Eighty-four age and sex-matched participants (28 migraine with aura, 28 migraine without aura, and 28 controls) were studied. No significant differences in somatosensory, cingulate gyrus, or V3A/MT+ cortical thickness were found between the groups, including analysis of specific subregions previously reported to be affected. Whole brain analysis found no regions of differential gray matter thickness between groups. A highly significant inverse correlation between age and whole brain and regional cortical thickness was identified. Power analyses indicate that even a small difference (∼0.07 to 0.14 mm) in cortical thickness could have been detected between groups given the sample size. INTERPRETATION: Using highly sensitive surface-based morphometry, no differences in cortical thickness between patients with migraine and controls could be identified.
OBJECTIVE: Previous studies have reported gray matter alterations in patients with migraine, particularly thinning of the cingulate gyrus, and thickening of the somatosensory cortex (SSC) and visual motion processing areas (V3A/MT+). We attempted to replicate these findings in a larger patient population. METHODS: Brain anatomy was collected with 3T MRI. Surface-based morphometry was used to segment each brain volume, reconstruct and inflate the cortical sheet, and estimate gray matter thickness. RESULTS: Eighty-four age and sex-matched participants (28 migraine with aura, 28 migraine without aura, and 28 controls) were studied. No significant differences in somatosensory, cingulate gyrus, or V3A/MT+ cortical thickness were found between the groups, including analysis of specific subregions previously reported to be affected. Whole brain analysis found no regions of differential gray matter thickness between groups. A highly significant inverse correlation between age and whole brain and regional cortical thickness was identified. Power analyses indicate that even a small difference (∼0.07 to 0.14 mm) in cortical thickness could have been detected between groups given the sample size. INTERPRETATION: Using highly sensitive surface-based morphometry, no differences in cortical thickness between patients with migraine and controls could be identified.
Authors: Xiao Han; Jorge Jovicich; David Salat; Andre van der Kouwe; Brian Quinn; Silvester Czanner; Evelina Busa; Jenni Pacheco; Marilyn Albert; Ronald Killiany; Paul Maguire; Diana Rosas; Nikos Makris; Anders Dale; Bradford Dickerson; Bruce Fischl Journal: Neuroimage Date: 2006-05-02 Impact factor: 6.556
Authors: Cristina Granziera; Alexandre F M DaSilva; Josh Snyder; David S Tuch; Nouchine Hadjikhani Journal: PLoS Med Date: 2006-10 Impact factor: 11.069
Authors: Andrew M Youssef; Allison Ludwick; Sophie L Wilcox; Alyssa Lebel; Ke Peng; Elisabeth Colon; Amy Danehy; Rami Burstein; Lino Becerra; David Borsook Journal: Hum Brain Mapp Date: 2017-05-31 Impact factor: 5.038
Authors: Larus S Gudmundsson; Ann I Scher; Sigurdur Sigurdsson; Mirjam I Geerlings; Jean-Sebastien Vidal; Gudny Eiriksdottir; Melissa I Garcia; Tamara B Harris; Olafur Kjartansson; Thor Aspelund; Mark A van Buchem; Vilmundur Gudnason; Lenore J Launer Journal: Neurology Date: 2013-05-22 Impact factor: 9.910