Literature DB >> 21910441

Malabaricone C from Myristica cinnamomea exhibits anti-quorum sensing activity.

Yee Meng Chong1, Wai Fong Yin, Chia Yong Ho, Mohamad Rais Mustafa, A Hamid A Hadi, Khalijah Awang, Putri Narrima, Chong-Lek Koh, David R Appleton, Kok-Gan Chan.   

Abstract

A methanol-soluble extract of the bark of Myristica cinnamomea was found to exhibit anti-quorum sensing activity, and subsequent bioassay-guided isolation led to the identification of the active compound malabaricone C (1). Compound 1 inhibited violacein production by Chromobacterium violaceum CV026 when grown in the presence of a cognate signaling molecule, N-3-oxohexanoyl-homoserine lactone. Furthermore, 1 inhibited the quorum sensing-regulated pyocyanin production and biofilm formation in Pseudomonas aeruginosa PAO1. These results suggest that the anti-quorum sensing activity of 1 and related molecules should be investigated further.

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Year:  2011        PMID： 21910441     DOI： 10.1021/np100872k

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  43 in total

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5.  Phenolic compounds from nutmeg (Myristica fragrans Houtt.) inhibit the endocannabinoid-modulating enzyme fatty acid amide hydrolase.

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8.  Quorum Sensing and NF-κB Inhibition of Synthetic Coumaperine Derivatives from Piper nigrum.

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Journal:  Molecules       Date:  2021-04-15       Impact factor: 4.411

9.  1-(4-Amino-2-hydroxyphenyl)ethanone from Phomopsis liquidambari showed quorum sensing inhibitory activity against Pseudomonas aeruginosa.

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10.  Caffeine as a potential quorum sensing inhibitor.

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