Literature DB >> 21909927

Analysis of chemotaxis in Dictyostelium.

Huaqing Cai1, Chuan-Hsiang Huang, Peter N Devreotes, Miho Iijima.   

Abstract

Dictyostelium discoideum is an excellent model organism for the study of directed cell migration, since Dictyostelium cells show robust chemotactic responses to the chemoattractant cAMP. Many powerful experimental tools are applicable, including forward and reverse genetics, biochemistry, microscopy, and proteomics. Recent studies have demonstrated that many components involved in chemotaxis are functionally conserved between human neutrophils and Dictyostelium amoebae. In this chapter, we describe how to define the functions of proteins that mediate and regulate cell motility, cell polarity, and directional sensing during chemotaxis in Dictyostelium.

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Year:  2012        PMID： 21909927      PMCID： PMC3381519          DOI： 10.1007/978-1-61779-166-6_26

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  18 in total

1.  Receptor-mediated activation of heterotrimeric G-proteins in living cells.

Authors:  C Janetopoulos; T Jin; P Devreotes
Journal:  Science       Date:  2001-03-23       Impact factor: 47.728

2.  Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis.

Authors:  Satoru Funamoto; Ruedi Meili; Susan Lee; Lisa Parry; Richard A Firtel
Journal:  Cell       Date:  2002-05-31       Impact factor: 41.582

3.  Tumor suppressor PTEN mediates sensing of chemoattractant gradients.

Authors:  Miho Iijima; Peter Devreotes
Journal:  Cell       Date:  2002-05-31       Impact factor: 41.582

4.  Novel mechanism of PTEN regulation by its phosphatidylinositol 4,5-bisphosphate binding motif is critical for chemotaxis.

Authors:  Miho Iijima; Yi Elaine Huang; Hongbo R Luo; Francisca Vazquez; Peter N Devreotes
Journal:  J Biol Chem       Date:  2004-02-05       Impact factor: 5.157

5.  Receptor-mediated regulation of PI3Ks confines PI(3,4,5)P3 to the leading edge of chemotaxing cells.

Authors:  Yi Elaine Huang; Miho Iijima; Carole A Parent; Satoru Funamoto; Richard A Firtel; Peter Devreotes
Journal:  Mol Biol Cell       Date:  2003-02-06       Impact factor: 4.138

6.  G protein signaling events are activated at the leading edge of chemotactic cells.

Authors:  C A Parent; B J Blacklock; W M Froehlich; D B Murphy; P N Devreotes
Journal:  Cell       Date:  1998-10-02       Impact factor: 41.582

Review 7.  Molecular genetics of signal transduction in Dictyostelium.

Authors:  C A Parent; P N Devreotes
Journal:  Annu Rev Biochem       Date:  1996       Impact factor: 23.643

8.  A novel cytosolic regulator, Pianissimo, is required for chemoattractant receptor and G protein-mediated activation of the 12 transmembrane domain adenylyl cyclase in Dictyostelium.

Authors:  M Y Chen; Y Long; P N Devreotes
Journal:  Genes Dev       Date:  1997-12-01       Impact factor: 11.361

9.  Chemoattractant-induced Ras activation during Dictyostelium aggregation.

Authors:  Helmut Kae; Chinten James Lim; George B Spiegelman; Gerald Weeks
Journal:  EMBO Rep       Date:  2004-05-14       Impact factor: 8.807

10.  Role of phosphatidylinositol 3' kinase and a downstream pleckstrin homology domain-containing protein in controlling chemotaxis in dictyostelium.

Authors:  S Funamoto; K Milan; R Meili; R A Firtel
Journal:  J Cell Biol       Date:  2001-05-14       Impact factor: 10.539
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  15 in total

1.  Multiscale mechanisms of cell migration during development: theory and experiment.

Authors:  Rebecca McLennan; Louise Dyson; Katherine W Prather; Jason A Morrison; Ruth E Baker; Philip K Maini; Paul M Kulesa
Journal:  Development       Date:  2012-07-04       Impact factor: 6.868

2.  Rho GTPases orient directional sensing in chemotaxis.

Authors:  Yu Wang; Hiroshi Senoo; Hiromi Sesaki; Miho Iijima
Journal:  Proc Natl Acad Sci U S A       Date:  2013-11-18       Impact factor: 11.205

3.  Nucleocytoplasmic shuttling of a GATA transcription factor functions as a development timer.

Authors:  Huaqing Cai; Mariko Katoh-Kurasawa; Tetsuya Muramoto; Balaji Santhanam; Yu Long; Lei Li; Masahiro Ueda; Pablo A Iglesias; Gad Shaulsky; Peter N Devreotes
Journal:  Science       Date:  2014-03-21       Impact factor: 47.728

4.  Engineering PTEN function: membrane association and activity.

Authors:  Jr-Ming Yang; Hoai-Nghia Nguyen; Hiromi Sesaki; Peter N Devreotes; Miho Iijima
Journal:  Methods       Date:  2014-10-22       Impact factor: 3.608

5.  Spatiotemporal dynamics of membrane surface charge regulates cell polarity and migration.

Authors:  Debojyoti Biswas; Dhiman Sankar Pal; Tatsat Banerjee; Yuchuan Miao; Pablo A Iglesias; Peter N Devreotes
Journal:  Nat Cell Biol       Date:  2022-10-06       Impact factor: 28.213

6.  Identification of a farnesol analog as a Ras function inhibitor using both an in vivo Ras activation sensor and a phenotypic screening approach.

Authors:  Kamalakkannan Srinivasan; Thangaiah Subramanian; H Peter Spielmann; Chris Janetopoulos
Journal:  Mol Cell Biochem       Date:  2013-11-06       Impact factor: 3.396

7.  Assessment of Dictyostelium discoideum Response to Acute Mechanical Stimulation.

Authors:  Yulia Artemenko; Peter N Devreotes
Journal:  J Vis Exp       Date:  2017-11-09       Impact factor: 1.355

8.  Engineering ePTEN, an enhanced PTEN with increased tumor suppressor activities.

Authors:  Hoai-Nghia Nguyen; Jr-Ming Yang; Yashar Afkari; Ben Ho Park; Hiromi Sesaki; Peter N Devreotes; Miho Iijima
Journal:  Proc Natl Acad Sci U S A       Date:  2014-06-16       Impact factor: 11.205

9.  A new class of cancer-associated PTEN mutations defined by membrane translocation defects.

Authors:  H-N Nguyen; J-M Yang; M Rahdar; M Keniry; K F Swaney; R Parsons; B H Park; H Sesaki; P N Devreotes; M Iijima
Journal:  Oncogene       Date:  2014-09-29       Impact factor: 9.867

10.  Mechanism of human PTEN localization revealed by heterologous expression in Dictyostelium.

Authors:  H N Nguyen; Y Afkari; H Senoo; H Sesaki; P N Devreotes; M Iijima
Journal:  Oncogene       Date:  2013-12-02       Impact factor: 9.867
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