K Pourhamidi1, L B Dahlin, K Boman, O Rolandsson. 1. Department of Public Health and Clinical Medicine, Family Medicine, Umeå University, 901 85 Umeå, Sweden. kaveh.pourhamidi@fammed.umu.se
Abstract
AIMS/HYPOTHESIS: High levels of serum heat shock protein 27 (sHSP27) have been associated with distal symmetric polyneuropathy in patients with type 1 diabetes. Our objective was to investigate the association between sHSP27, neuropathic signs and nerve function in individuals with normal glucose tolerance (NGT), impaired glucose tolerance (IGT) and type 2 diabetes. METHODS: Participants were recruited consecutively from the population-based Västerbotten Intervention Program (NGT, n = 39, IGT, n = 29, and type 2 diabetes, n = 51) and were matched for age and sex. sHSP27 levels were measured and nerve conduction studies were performed (peroneal and sural nerves). z Scores for each nerve conduction measure were calculated and compiled into a composite z score for the leg. Neuropathy disability score (NDS) was used to assess neuropathic signs. RESULTS: Patients with diabetes had significantly lower sHSP27 levels (geometric mean sHSP27 206 pg/ml, 95% CI 142, 299) than those with IGT (geometric mean sHSP27 455 pg/ml, 95% CI 319, 650, p < 0.05) and controls (geometric mean sHSP27 361 pg/ml, 95% CI 282, 461, p < 0.05). Participants with few signs of neuropathy (first tertile, NDS ≤2) had significantly higher sHSP27 levels (geometric mean sHSP27 401 pg/ml, 95% CI 310, 520) than participants with many signs (third tertile, NDS ≥7) (geometric mean sHSP27 192 pg/ml, 95% CI 128, 288, p = 0.007). The highest sHSP27 tertile was associated with better nerve function, adjusted for age, sex, statin medication and HbA(1c) (OR 2.51, 95% CI 1.25, 5.05, p < 0.05). CONCLUSIONS/ INTERPRETATION: High sHSP27 levels were associated with better nerve function and fewer neuropathic signs in NGT, IGT and type 2 diabetes.
AIMS/HYPOTHESIS: High levels of serum heat shock protein 27 (sHSP27) have been associated with distal symmetric polyneuropathy in patients with type 1 diabetes. Our objective was to investigate the association between sHSP27, neuropathic signs and nerve function in individuals with normal glucose tolerance (NGT), impaired glucose tolerance (IGT) and type 2 diabetes. METHODS:Participants were recruited consecutively from the population-based Västerbotten Intervention Program (NGT, n = 39, IGT, n = 29, and type 2 diabetes, n = 51) and were matched for age and sex. sHSP27 levels were measured and nerve conduction studies were performed (peroneal and sural nerves). z Scores for each nerve conduction measure were calculated and compiled into a composite z score for the leg. Neuropathy disability score (NDS) was used to assess neuropathic signs. RESULTS:Patients with diabetes had significantly lower sHSP27 levels (geometric mean sHSP27 206 pg/ml, 95% CI 142, 299) than those with IGT (geometric mean sHSP27 455 pg/ml, 95% CI 319, 650, p < 0.05) and controls (geometric mean sHSP27 361 pg/ml, 95% CI 282, 461, p < 0.05). Participants with few signs of neuropathy (first tertile, NDS ≤2) had significantly higher sHSP27 levels (geometric mean sHSP27 401 pg/ml, 95% CI 310, 520) than participants with many signs (third tertile, NDS ≥7) (geometric mean sHSP27 192 pg/ml, 95% CI 128, 288, p = 0.007). The highest sHSP27 tertile was associated with better nerve function, adjusted for age, sex, statin medication and HbA(1c) (OR 2.51, 95% CI 1.25, 5.05, p < 0.05). CONCLUSIONS/ INTERPRETATION: High sHSP27 levels were associated with better nerve function and fewer neuropathic signs in NGT, IGT and type 2 diabetes.
Authors: S Thrainsdottir; R A Malik; I Rosén; F Jakobsson; E Bakhtadze; J Petersson; G Sundkvist; L B Dahlin Journal: Acta Neurol Scand Date: 2008-12-22 Impact factor: 3.209
Authors: Soley Thrainsdottir; Rayez A Malik; Lars B Dahlin; Peter Wiksell; Karl F Eriksson; Ingmar Rosén; Jesper Petersson; Douglas A Greene; Göran Sundkvist Journal: Diabetes Date: 2003-10 Impact factor: 9.461
Authors: Christian Schmeer; Adriana Gámez; Svetlana Tausch; Otto W Witte; Stefan Isenmann Journal: Invest Ophthalmol Vis Sci Date: 2008-06-19 Impact factor: 4.799
Authors: Oleg V Evgrafov; Irena Mersiyanova; Joy Irobi; Ludo Van Den Bosch; Ines Dierick; Conrad L Leung; Olga Schagina; Nathalie Verpoorten; Katrien Van Impe; Valeriy Fedotov; Elena Dadali; Michaela Auer-Grumbach; Christian Windpassinger; Klaus Wagner; Zoran Mitrovic; David Hilton-Jones; Kevin Talbot; Jean-Jacques Martin; Natalia Vasserman; Svetlana Tverskaya; Alexander Polyakov; Ronald K H Liem; Jan Gettemans; Wim Robberecht; Peter De Jonghe; Vincent Timmerman Journal: Nat Genet Date: 2004-05-02 Impact factor: 38.330
Authors: Davina Burt; Graziella Bruno; Nish Chaturvedi; Casper Schalkwijk; Coen D Stehouwer; Daniel R Witte; John H Fuller; Silvia Pinach; Paolo Cavallo Perin; Gabriella Gruden Journal: Diabetes Care Date: 2009-04-14 Impact factor: 17.152
Authors: Malin Zimmerman; Sara Rolandsson Enes; Hanna Skärstrand; Kaveh Pourhamidi; Anders Gottsäter; Per Wollmer; Olov Rolandsson; Gunilla Westergren-Thorsson; Lars B Dahlin Journal: J Clin Transl Endocrinol Date: 2017-03-20