Literature DB >> 2190974

A comparison of aztreonam/metronidazole and cefotaxime/metronidazole in elective colorectal surgery: antimicrobial prophylaxis must include gram-positive cover.

D L Morris1, S R Wilson, J Pain, K F Edwardson, J Jones, C Strachan, R Slack.   

Abstract

Aztreonam/metronidazole and cefotaxime/metronidazole were compared in a prospective trial in 154 patients undergoing elective colorectal surgery. Three antibiotic doses were given over 16 hours. A significant excess of wound sepsis in the aztreonam group was seen (23/71 vs 9/70 chi 2 6.60; P less than 0.01). Sepsis was almost invariably due to Gram-positive organisms and, in particular, Staphylococcus aureus.

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Year:  1990        PMID： 2190974     DOI： 10.1093/jac/25.4.673

Source DB:  PubMed          Journal:  J Antimicrob Chemother        ISSN： 0305-7453            Impact factor:   5.790


  3 in total

Review 1.  Cefotaxime. An update of its pharmacology and therapeutic use.

Authors:  P A Todd; R N Brogden
Journal:  Drugs       Date:  1990-10       Impact factor: 9.546

2.  Epidemiology of methicillin-resistant Staphylococcus aureus carriage and MRSA surgical site infections in patients undergoing colorectal surgery: a cohort study in two centers.

Authors:  Benedikt Huttner; Ari A Robicsek; Pascal Gervaz; Eli N Perencevich; Eduardo Schiffer; Jacques Schrenzel; Stephan Harbarth
Journal:  Surg Infect (Larchmt)       Date:  2012-12-16       Impact factor: 2.150

3.  Ciprofloxacin infusion versus third generation cephalosporin as a surgical prophylaxis for percutaneous nephrolithotomy: a randomized study.

Authors:  Mohamed Omar; Mohamed Selim; Eid El Sherif; Nesma Abozaid; Eman Farag; Mohamed El Garabawey; Fouad Zanaty
Journal:  Cent European J Urol       Date:  2019-01-14
  3 in total

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