BACKGROUND: Lung MRI volumetrics may be valuable for fetal assessment following early preterm premature rupture of the foetal membranes (pPROM). OBJECTIVE: To evaluate the predictive value of MRI lung volumetrics after pPROM. MATERIALS AND METHODS: Retrospective cohort study of 40 fetuses after pPROM in a large, tertiary, perinatal referral center. Fetuses underwent MRI lung volumetrics. Estimated lung volume was expressed as percentage of expected lung volume (our own normal references). Primary outcome was neonatal mortality due to respiratory distress before discharge from hospital. RESULTS: Gestational age range was 16-27 weeks. Estimated-to-expected lung volume was 73% in non-survivors and 102% in survivors (P < 0.05). There were no survivors with a lung volume less than 60% of expected. By logistic regression, mortality could be predicted with a sensitivity of 80%, specificity of 86% and accuracy of 85%. CONCLUSION: Fetal MR lung volumetrics may be useful for predicting mortality due to respiratory distress in children with early gestational pPROM.
BACKGROUND: Lung MRI volumetrics may be valuable for fetal assessment following early preterm premature rupture of the foetal membranes (pPROM). OBJECTIVE: To evaluate the predictive value of MRI lung volumetrics after pPROM. MATERIALS AND METHODS: Retrospective cohort study of 40 fetuses after pPROM in a large, tertiary, perinatal referral center. Fetuses underwent MRI lung volumetrics. Estimated lung volume was expressed as percentage of expected lung volume (our own normal references). Primary outcome was neonatal mortality due to respiratory distress before discharge from hospital. RESULTS: Gestational age range was 16-27 weeks. Estimated-to-expected lung volume was 73% in non-survivors and 102% in survivors (P < 0.05). There were no survivors with a lung volume less than 60% of expected. By logistic regression, mortality could be predicted with a sensitivity of 80%, specificity of 86% and accuracy of 85%. CONCLUSION: Fetal MR lung volumetrics may be useful for predicting mortality due to respiratory distress in children with early gestational pPROM.
Authors: Inga Sandaite; Filip Claus; Frederik De Keyzer; Elisa Donè; Tim Van Mieghem; Leonardo Gucciardo; Philip DeKoninck; Jacques Jani; Mieke Cannie; Jan A Deprest Journal: Fetal Diagn Ther Date: 2010-10-20 Impact factor: 2.587
Authors: Mieke Cannie; Jacques C Jani; Frederik De Keyzer; Roland Devlieger; Dominique Van Schoubroeck; Ingrid Witters; Guy Marchal; Steven Dymarkowski; Jan A Deprest Journal: Radiology Date: 2006-10-19 Impact factor: 11.105
Authors: Mara J Dinsmoor; Rebecca Bachman; Elaine I Haney; Marci Goldstein; William Mackendrick Journal: Am J Obstet Gynecol Date: 2004-01 Impact factor: 8.661
Authors: Lisa Story; Tong Zhang; Johannes K Steinweg; Jana Hutter; Jacqueline Matthew; Theodore Dassios; Paul T Seed; Dharmintra Pasupathy; Joanna Allsop; Joseph V Hajnal; Anne Greenough; Andrew H Shennan; Mary Rutherford Journal: Pediatr Res Date: 2019-12-07 Impact factor: 3.756