OBJECTIVE: This study aimed to assess the serum levels of vascular endothelial growth factor in oral squamous cell carcinoma patients before and after surgical therapy, to compare these values with those of healthy individuals using ELISA, and to evaluate if any correlation existed between vascular endothelial growth factor levels and TNM stage or histolopathologic grade of the tumor. METHOD AND MATERIALS: The study included three groups: group A1 consisted of 31 oral squamous cell carcinoma patients who had not received any prior treatment; group A2 consisted of the same 31 oral squamous cell carcinoma patients who hadundergone radical surgical excision 1 month prior but no adjuvant therapy; and group B (control group) consisted of 16 healthy individuals. The serum vascular endothelial growth factor levels were assessed using the ELISA kit. RESULTS: The vascular endothelial growth factor levels of preoperative oral squamous cell carcinoma patients were found to be three times higher than those of controls, and this difference was found to be statistically significant. The postoperative vascular endothelial growth factor levels had decreased 1 month after surgery but did not decrease to baseline levels. The vascular endothelial growth factor levels increased progressively with the TNM stage and histologic grade of tumor, but no definite correlation between the two could be found. CONCLUSION: Vascular endothelial growth factor is an important marker of angiogenesis, as the vascular endothelial growth factor levels of the oral squamous cell carcinoma groups remained significantly elevated compared to that of controls. Though no significant difference was found between the pre- and postoperative oral squamous cell carcinoma groups, it can be suggested that successful treatment may reduce serum vascular endothelial growth factor levels if the time period of postoperative sample collection is increased. Only then can the utility of vascular endothelial growth factor as marker for assessing the effectiveness of surgical therapy or as a prognostic indicator be commented upon.
RCT Entities:
OBJECTIVE: This study aimed to assess the serum levels of vascular endothelial growth factor in oral squamous cell carcinomapatients before and after surgical therapy, to compare these values with those of healthy individuals using ELISA, and to evaluate if any correlation existed between vascular endothelial growth factor levels and TNM stage or histolopathologic grade of the tumor. METHOD AND MATERIALS: The study included three groups: group A1 consisted of 31 oral squamous cell carcinomapatients who had not received any prior treatment; group A2 consisted of the same 31 oral squamous cell carcinomapatients who had undergone radical surgical excision 1 month prior but no adjuvant therapy; and group B (control group) consisted of 16 healthy individuals. The serum vascular endothelial growth factor levels were assessed using the ELISA kit. RESULTS: The vascular endothelial growth factor levels of preoperative oral squamous cell carcinomapatients were found to be three times higher than those of controls, and this difference was found to be statistically significant. The postoperative vascular endothelial growth factor levels had decreased 1 month after surgery but did not decrease to baseline levels. The vascular endothelial growth factor levels increased progressively with the TNM stage and histologic grade of tumor, but no definite correlation between the two could be found. CONCLUSION:Vascular endothelial growth factor is an important marker of angiogenesis, as the vascular endothelial growth factor levels of the oral squamous cell carcinoma groups remained significantly elevated compared to that of controls. Though no significant difference was found between the pre- and postoperative oral squamous cell carcinoma groups, it can be suggested that successful treatment may reduce serum vascular endothelial growth factor levels if the time period of postoperative sample collection is increased. Only then can the utility of vascular endothelial growth factor as marker for assessing the effectiveness of surgical therapy or as a prognostic indicator be commented upon.
Authors: André R C P de Oliveira; Márcia M U Castanhole-Nunes; Patrícia M Biselli-Chicote; Érika C Pavarino; Rita de C M A da Silva; Renato F da Silva; Eny M Goloni-Bertollo Journal: Arch Med Sci Date: 2020-08-10 Impact factor: 3.318
Authors: Patrícia Matos Biselli-Chicote; Joice Matos Biselli; Bianca R Cunha; Rodrigo Castro; José Victor Maniglia; Dalísio de Santi Neto; Eloiza Helena Tajara; José Franscisco de Góis Filho; Erica Erina Fukuyama; Érika Cristina Pavarino; Eny Maria Goloni-Bertollo Journal: Asian Pac J Cancer Prev Date: 2017-08-27